Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★

Animal models of intracerebral hemorrhage were established by injection of autologous blood into the caudate nucleus in rats. Cell apoptosis was measured by flow cytometry and immunohistochemical staining of the p75 neurotrophin receptor. p75 neurotrophin receptor protein was detected by immunohisto...

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Autores principales: He, Baixiang, Bao, Gang, Guo, Shiwen, Xu, Gaofeng, Li, Qi, Wang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Technique and Method: Brain Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346983/
https://www.ncbi.nlm.nih.gov/pubmed/25745449
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.08.005
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author He, Baixiang
Bao, Gang
Guo, Shiwen
Xu, Gaofeng
Li, Qi
Wang, Ning
author_facet He, Baixiang
Bao, Gang
Guo, Shiwen
Xu, Gaofeng
Li, Qi
Wang, Ning
author_sort He, Baixiang
collection PubMed
description Animal models of intracerebral hemorrhage were established by injection of autologous blood into the caudate nucleus in rats. Cell apoptosis was measured by flow cytometry and immunohistochemical staining of the p75 neurotrophin receptor. p75 neurotrophin receptor protein was detected by immunohistochemistry. p75 neurotrophin receptor mRNA was examined by quantitative real-time polymerase chain reactions. At 24 hours after modeling, cellular apoptosis occured around hematoma with upregulation of p75 neurotrophin receptor protein and mRNA was observed, which directly correlated to apoptosis. This observation indicated that p75 neurotrophin receptor upregulation was associated with cell apoptosis around hematomas after intracerebral hemorrhage.
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spelling pubmed-43469832015-03-05 Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★ He, Baixiang Bao, Gang Guo, Shiwen Xu, Gaofeng Li, Qi Wang, Ning Neural Regen Res Technique and Method: Brain Injury and Neuroregeneration Animal models of intracerebral hemorrhage were established by injection of autologous blood into the caudate nucleus in rats. Cell apoptosis was measured by flow cytometry and immunohistochemical staining of the p75 neurotrophin receptor. p75 neurotrophin receptor protein was detected by immunohistochemistry. p75 neurotrophin receptor mRNA was examined by quantitative real-time polymerase chain reactions. At 24 hours after modeling, cellular apoptosis occured around hematoma with upregulation of p75 neurotrophin receptor protein and mRNA was observed, which directly correlated to apoptosis. This observation indicated that p75 neurotrophin receptor upregulation was associated with cell apoptosis around hematomas after intracerebral hemorrhage. Medknow Publications & Media Pvt Ltd 2012-03-15 /pmc/articles/PMC4346983/ /pubmed/25745449 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.08.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technique and Method: Brain Injury and Neuroregeneration
He, Baixiang
Bao, Gang
Guo, Shiwen
Xu, Gaofeng
Li, Qi
Wang, Ning
Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
title Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
title_full Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
title_fullStr Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
title_full_unstemmed Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
title_short Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
title_sort association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage★
topic Technique and Method: Brain Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346983/
https://www.ncbi.nlm.nih.gov/pubmed/25745449
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.08.005
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