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Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★
The present study investigated the disease trajectory of vascular cognitive impairment using the entropy of information in a neural network mathematical simulation based on the free radical and excitatory amino acids theories. Glutamate, malondialdehyde, and inducible nitric oxide synthase content w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347011/ https://www.ncbi.nlm.nih.gov/pubmed/25745466 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.09.010 |
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author | Liu, Lin Huo, Ju Zhao, Ying Tian, Yu |
author_facet | Liu, Lin Huo, Ju Zhao, Ying Tian, Yu |
author_sort | Liu, Lin |
collection | PubMed |
description | The present study investigated the disease trajectory of vascular cognitive impairment using the entropy of information in a neural network mathematical simulation based on the free radical and excitatory amino acids theories. Glutamate, malondialdehyde, and inducible nitric oxide synthase content was significantly elevated, but acetylcholine, catalase, superoxide dismutase, glutathione peroxidase and constitutive nitric oxide synthase content was significantly decreased in our vascular cognitive impairment model. The fitting curves for each factor were obtained using Matlab software. Nineteen, 30 and 49 days post ischemia were the main output time frames of the influence of these seven factors. Our results demonstrated that vascular cognitive impairment involves multiple factors. These factors include excitatory amino acid toxicity and nitric oxide toxicity. These toxicities disrupt the dynamic equilibrium of the production and removal of oxygen free radicals after cerebral ischemia, reducing the ability to clear oxygen free radicals and worsening brain injury. |
format | Online Article Text |
id | pubmed-4347011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43470112015-03-05 Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ Liu, Lin Huo, Ju Zhao, Ying Tian, Yu Neural Regen Res Techniques and Method: Emerging Technology in Neuroregeneration The present study investigated the disease trajectory of vascular cognitive impairment using the entropy of information in a neural network mathematical simulation based on the free radical and excitatory amino acids theories. Glutamate, malondialdehyde, and inducible nitric oxide synthase content was significantly elevated, but acetylcholine, catalase, superoxide dismutase, glutathione peroxidase and constitutive nitric oxide synthase content was significantly decreased in our vascular cognitive impairment model. The fitting curves for each factor were obtained using Matlab software. Nineteen, 30 and 49 days post ischemia were the main output time frames of the influence of these seven factors. Our results demonstrated that vascular cognitive impairment involves multiple factors. These factors include excitatory amino acid toxicity and nitric oxide toxicity. These toxicities disrupt the dynamic equilibrium of the production and removal of oxygen free radicals after cerebral ischemia, reducing the ability to clear oxygen free radicals and worsening brain injury. Medknow Publications & Media Pvt Ltd 2012-03-25 /pmc/articles/PMC4347011/ /pubmed/25745466 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.09.010 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Techniques and Method: Emerging Technology in Neuroregeneration Liu, Lin Huo, Ju Zhao, Ying Tian, Yu Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
title | Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
title_full | Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
title_fullStr | Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
title_full_unstemmed | Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
title_short | Information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
title_sort | information entropy-based fitting of the disease trajectory of brain ischemia-induced vascular cognitive impairment★ |
topic | Techniques and Method: Emerging Technology in Neuroregeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347011/ https://www.ncbi.nlm.nih.gov/pubmed/25745466 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.09.010 |
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