Pharmacological classes that extend lifespan of Caenorhabditis elegans

Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is kno...

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Autores principales: Carretero, Maria, Gomez-Amaro, Rafael L., Petrascheck, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347486/
https://www.ncbi.nlm.nih.gov/pubmed/25784926
http://dx.doi.org/10.3389/fgene.2015.00077
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author Carretero, Maria
Gomez-Amaro, Rafael L.
Petrascheck, Michael
author_facet Carretero, Maria
Gomez-Amaro, Rafael L.
Petrascheck, Michael
author_sort Carretero, Maria
collection PubMed
description Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
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spelling pubmed-43474862015-03-17 Pharmacological classes that extend lifespan of Caenorhabditis elegans Carretero, Maria Gomez-Amaro, Rafael L. Petrascheck, Michael Front Genet Genetics Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan. Frontiers Media S.A. 2015-03-03 /pmc/articles/PMC4347486/ /pubmed/25784926 http://dx.doi.org/10.3389/fgene.2015.00077 Text en Copyright © 2015 Carretero, Gomez-Amaro and Petrascheck. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Carretero, Maria
Gomez-Amaro, Rafael L.
Petrascheck, Michael
Pharmacological classes that extend lifespan of Caenorhabditis elegans
title Pharmacological classes that extend lifespan of Caenorhabditis elegans
title_full Pharmacological classes that extend lifespan of Caenorhabditis elegans
title_fullStr Pharmacological classes that extend lifespan of Caenorhabditis elegans
title_full_unstemmed Pharmacological classes that extend lifespan of Caenorhabditis elegans
title_short Pharmacological classes that extend lifespan of Caenorhabditis elegans
title_sort pharmacological classes that extend lifespan of caenorhabditis elegans
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347486/
https://www.ncbi.nlm.nih.gov/pubmed/25784926
http://dx.doi.org/10.3389/fgene.2015.00077
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