A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale

BACKGROUND: Human mitochondrial CYP11B1 catalyzes a one-step regio- and stereoselective 11β-hydroxylation of 11-deoxycortisol yielding cortisol which constitutes not only the major human stress hormone but also represents a commercially relevant therapeutic drug due to its anti-inflammatory and immu...

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Detalles Bibliográficos
Autores principales: Schiffer, Lina, Anderko, Simone, Hobler, Anna, Hannemann, Frank, Kagawa, Norio, Bernhardt, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347555/
https://www.ncbi.nlm.nih.gov/pubmed/25880059
http://dx.doi.org/10.1186/s12934-015-0209-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347555/
https://www.ncbi.nlm.nih.gov/pubmed/25880059
http://dx.doi.org/10.1186/s12934-015-0209-5

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