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Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism

Biotin-mediated carboxylation of short-chain fatty acid coenzyme A esters is a key step in lipid biosynthesis that is carried out by multienzyme complexes to extend fatty acids by one methylene group. Pathogenic mycobacteria have an unusually high redundancy of carboxyltransferase genes and biotin c...

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Detalles Bibliográficos
Autores principales:	Ehebauer, Matthias T., Zimmermann, Michael, Jakobi, Arjen J., Noens, Elke E., Laubitz, Daniel, Cichocki, Bogdan, Marrakchi, Hedia, Lanéelle, Marie-Antoinette, Daffé, Mamadou, Sachse, Carsten, Dziembowski, Andrzej, Sauer, Uwe, Wilmanns, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347857/ https://www.ncbi.nlm.nih.gov/pubmed/25695631 http://dx.doi.org/10.1371/journal.ppat.1004623

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