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Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review
Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347975/ https://www.ncbi.nlm.nih.gov/pubmed/25734582 http://dx.doi.org/10.1371/journal.pone.0119908 |
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author | Nolan, Vikki G. Nottage, Kerri A. Cole, Elliott W. Hankins, Jane S. Gurney, James G. |
author_facet | Nolan, Vikki G. Nottage, Kerri A. Cole, Elliott W. Hankins, Jane S. Gurney, James G. |
author_sort | Nolan, Vikki G. |
collection | PubMed |
description | Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine the prevalence and magnitude of each in patients with SCD through a systematic review conducted according to PRISMA guidelines. From a PubMed search, 34 potential articles were identified and 15 met eligibility criteria for inclusion. Definitions of deficiency and insufficiency varied greatly across studies making direct comparisons difficult. This review provides evidence to suggest that suboptimal vitamin D levels are highly prevalent among those with SCD, far more so than in comparable non-SCD patients or matched control populations. Defining deficiency as vitamin D <20ng/mL, prevalence estimates in SCD populations range from 56.4% to 96.4%. When compared with results from the population-based National Health and Nutrition Examination Survey, however, the general African American population appeared to have a similarly high prevalence of vitamin D deficiency. African American patients with and without SCD were both substantially higher than that of Caucasians. What remains to be determined is whether there are adverse health effects for patients with SCD because of concurrent vitamin D deficiency. |
format | Online Article Text |
id | pubmed-4347975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43479752015-03-06 Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review Nolan, Vikki G. Nottage, Kerri A. Cole, Elliott W. Hankins, Jane S. Gurney, James G. PLoS One Research Article Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine the prevalence and magnitude of each in patients with SCD through a systematic review conducted according to PRISMA guidelines. From a PubMed search, 34 potential articles were identified and 15 met eligibility criteria for inclusion. Definitions of deficiency and insufficiency varied greatly across studies making direct comparisons difficult. This review provides evidence to suggest that suboptimal vitamin D levels are highly prevalent among those with SCD, far more so than in comparable non-SCD patients or matched control populations. Defining deficiency as vitamin D <20ng/mL, prevalence estimates in SCD populations range from 56.4% to 96.4%. When compared with results from the population-based National Health and Nutrition Examination Survey, however, the general African American population appeared to have a similarly high prevalence of vitamin D deficiency. African American patients with and without SCD were both substantially higher than that of Caucasians. What remains to be determined is whether there are adverse health effects for patients with SCD because of concurrent vitamin D deficiency. Public Library of Science 2015-03-03 /pmc/articles/PMC4347975/ /pubmed/25734582 http://dx.doi.org/10.1371/journal.pone.0119908 Text en © 2015 Nolan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nolan, Vikki G. Nottage, Kerri A. Cole, Elliott W. Hankins, Jane S. Gurney, James G. Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review |
title | Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review |
title_full | Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review |
title_fullStr | Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review |
title_full_unstemmed | Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review |
title_short | Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review |
title_sort | prevalence of vitamin d deficiency in sickle cell disease: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347975/ https://www.ncbi.nlm.nih.gov/pubmed/25734582 http://dx.doi.org/10.1371/journal.pone.0119908 |
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