Carbonic Anhydrase-8 Regulates Inflammatory Pain by Inhibiting the ITPR1-Cytosolic Free Calcium Pathway

Calcium dysregulation is causally linked with various forms of neuropathology including seizure disorders, multiple sclerosis, Huntington’s disease, Alzheimer’s, spinal cerebellar ataxia (SCA) and chronic pain. Carbonic anhydrase-8 (Car8) is an allosteric inhibitor of inositol trisphosphate receptor...

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Detalles Bibliográficos
Autores principales: Zhuang, Gerald Z., Keeler, Benjamin, Grant, Jeff, Bianchi, Laura, Fu, Eugene S., Zhang, Yan Ping, Erasso, Diana M., Cui, Jian-Guo, Wiltshire, Tim, Li, Qiongzhen, Hao, Shuanglin, Sarantopoulos, Konstantinos D., Candiotti, Keith, Wishnek, Sarah M., Smith, Shad B., Maixner, William, Diatchenko, Luda, Martin, Eden R., Levitt, Roy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347988/
https://www.ncbi.nlm.nih.gov/pubmed/25734498
http://dx.doi.org/10.1371/journal.pone.0118273

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