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Korean Medication Algorithm Project for Bipolar Disorder: third revision

OBJECTIVE: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014). METHODS: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment...

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Autores principales: Woo, Young Sup, Lee, Jung Goo, Jeong, Jong-Hyun, Kim, Moon-Doo, Sohn, Inki, Shim, Se-Hoon, Jon, Duk-In, Seo, Jeong Seok, Shin, Young-Chul, Min, Kyung Joon, Yoon, Bo-Hyun, Bahk, Won-Myong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348143/
https://www.ncbi.nlm.nih.gov/pubmed/25750530
http://dx.doi.org/10.2147/NDT.S77838
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author Woo, Young Sup
Lee, Jung Goo
Jeong, Jong-Hyun
Kim, Moon-Doo
Sohn, Inki
Shim, Se-Hoon
Jon, Duk-In
Seo, Jeong Seok
Shin, Young-Chul
Min, Kyung Joon
Yoon, Bo-Hyun
Bahk, Won-Myong
author_facet Woo, Young Sup
Lee, Jung Goo
Jeong, Jong-Hyun
Kim, Moon-Doo
Sohn, Inki
Shim, Se-Hoon
Jon, Duk-In
Seo, Jeong Seok
Shin, Young-Chul
Min, Kyung Joon
Yoon, Bo-Hyun
Bahk, Won-Myong
author_sort Woo, Young Sup
collection PubMed
description OBJECTIVE: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014). METHODS: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. RESULTS: The treatment of choice (TOC) for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS) and an atypical antipsychotic (AAP); the TOC for acute mild depression was monotherapy with MS or AAP; and the TOC for moderate or severe depression was MS plus AAP/antidepressant. The first-line maintenance treatment following mania or depression was MS monotherapy or MS plus AAP; the first-line treatment after mania was AAP monotherapy; and the first-line treatment after depression was lamotrigine (LTG) monotherapy, LTG plus MS/AAP, or MS plus AAP plus LTG. The first-line treatment strategy for mania in children and adolescents was MS plus AAP or AAP monotherapy. For geriatric bipolar patients, the TOC for mania was AAP/MS monotherapy, and the TOC for depression was AAP plus MS or AAP monotherapy. CONCLUSION: The expert consensus in the KMAP-BP 2014 differed from that in previous publications; most notably, the preference for AAP was increased in the treatment of acute mania, depression, and maintenance treatment. There was increased expert preference for the use of AAP and LTG. The major limitation of the present study is that it was based on the consensus of Korean experts rather than on experimental evidence.
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spelling pubmed-43481432015-03-06 Korean Medication Algorithm Project for Bipolar Disorder: third revision Woo, Young Sup Lee, Jung Goo Jeong, Jong-Hyun Kim, Moon-Doo Sohn, Inki Shim, Se-Hoon Jon, Duk-In Seo, Jeong Seok Shin, Young-Chul Min, Kyung Joon Yoon, Bo-Hyun Bahk, Won-Myong Neuropsychiatr Dis Treat Original Research OBJECTIVE: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014). METHODS: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. RESULTS: The treatment of choice (TOC) for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS) and an atypical antipsychotic (AAP); the TOC for acute mild depression was monotherapy with MS or AAP; and the TOC for moderate or severe depression was MS plus AAP/antidepressant. The first-line maintenance treatment following mania or depression was MS monotherapy or MS plus AAP; the first-line treatment after mania was AAP monotherapy; and the first-line treatment after depression was lamotrigine (LTG) monotherapy, LTG plus MS/AAP, or MS plus AAP plus LTG. The first-line treatment strategy for mania in children and adolescents was MS plus AAP or AAP monotherapy. For geriatric bipolar patients, the TOC for mania was AAP/MS monotherapy, and the TOC for depression was AAP plus MS or AAP monotherapy. CONCLUSION: The expert consensus in the KMAP-BP 2014 differed from that in previous publications; most notably, the preference for AAP was increased in the treatment of acute mania, depression, and maintenance treatment. There was increased expert preference for the use of AAP and LTG. The major limitation of the present study is that it was based on the consensus of Korean experts rather than on experimental evidence. Dove Medical Press 2015-02-26 /pmc/articles/PMC4348143/ /pubmed/25750530 http://dx.doi.org/10.2147/NDT.S77838 Text en © 2015 Woo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Woo, Young Sup
Lee, Jung Goo
Jeong, Jong-Hyun
Kim, Moon-Doo
Sohn, Inki
Shim, Se-Hoon
Jon, Duk-In
Seo, Jeong Seok
Shin, Young-Chul
Min, Kyung Joon
Yoon, Bo-Hyun
Bahk, Won-Myong
Korean Medication Algorithm Project for Bipolar Disorder: third revision
title Korean Medication Algorithm Project for Bipolar Disorder: third revision
title_full Korean Medication Algorithm Project for Bipolar Disorder: third revision
title_fullStr Korean Medication Algorithm Project for Bipolar Disorder: third revision
title_full_unstemmed Korean Medication Algorithm Project for Bipolar Disorder: third revision
title_short Korean Medication Algorithm Project for Bipolar Disorder: third revision
title_sort korean medication algorithm project for bipolar disorder: third revision
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348143/
https://www.ncbi.nlm.nih.gov/pubmed/25750530
http://dx.doi.org/10.2147/NDT.S77838
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