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Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever
BACKGROUND: Familial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various con...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348162/ https://www.ncbi.nlm.nih.gov/pubmed/25887962 http://dx.doi.org/10.1186/s13052-015-0120-z |
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author | Uluca, Ünal Demir, Fikri Ece, Aydın Şen, Velat Güneş, Ali Aktar, Fesih Tan, İlhan Karabel, Duran Yazgan, Ümitcan Sabaz, Muhammed Nurullah |
author_facet | Uluca, Ünal Demir, Fikri Ece, Aydın Şen, Velat Güneş, Ali Aktar, Fesih Tan, İlhan Karabel, Duran Yazgan, Ümitcan Sabaz, Muhammed Nurullah |
author_sort | Uluca, Ünal |
collection | PubMed |
description | BACKGROUND: Familial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls. METHODS: Forty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography. RESULTS: Epicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV). CONCLUSION: Epicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients. |
format | Online Article Text |
id | pubmed-4348162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43481622015-03-05 Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever Uluca, Ünal Demir, Fikri Ece, Aydın Şen, Velat Güneş, Ali Aktar, Fesih Tan, İlhan Karabel, Duran Yazgan, Ümitcan Sabaz, Muhammed Nurullah Ital J Pediatr Research BACKGROUND: Familial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls. METHODS: Forty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography. RESULTS: Epicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV). CONCLUSION: Epicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients. BioMed Central 2015-02-22 /pmc/articles/PMC4348162/ /pubmed/25887962 http://dx.doi.org/10.1186/s13052-015-0120-z Text en © Uluca et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Uluca, Ünal Demir, Fikri Ece, Aydın Şen, Velat Güneş, Ali Aktar, Fesih Tan, İlhan Karabel, Duran Yazgan, Ümitcan Sabaz, Muhammed Nurullah Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever |
title | Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever |
title_full | Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever |
title_fullStr | Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever |
title_full_unstemmed | Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever |
title_short | Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever |
title_sort | assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial mediterranean fever |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348162/ https://www.ncbi.nlm.nih.gov/pubmed/25887962 http://dx.doi.org/10.1186/s13052-015-0120-z |
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