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Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM)
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to th...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348482/ https://www.ncbi.nlm.nih.gov/pubmed/25734639 http://dx.doi.org/10.1371/journal.pone.0118998 |
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author | Ahmadi, Amir Leipsic, Jonathon Feuchtner, Gudrun Gransar, Heidi Kalra, Dan Heo, Ran Achenbach, Stephan Andreini, Daniele Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Chinnaiyan, Kavitha Chow, Benjamin Cury, Ricardo C. Delago, Augustin Gomez, Millie J. Hadamitzky, Martin Hausleiter, Joerg Hindoyan, Niree Kaufmann, Philipp A. Kim, Yong-Jin Lin, Fay Maffei, Erica Pontone, Gianluca Raff, Gilbert L. Shaw, Leslee J. Villines, Todd C. Dunning, Allison Min, James K. |
author_facet | Ahmadi, Amir Leipsic, Jonathon Feuchtner, Gudrun Gransar, Heidi Kalra, Dan Heo, Ran Achenbach, Stephan Andreini, Daniele Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Chinnaiyan, Kavitha Chow, Benjamin Cury, Ricardo C. Delago, Augustin Gomez, Millie J. Hadamitzky, Martin Hausleiter, Joerg Hindoyan, Niree Kaufmann, Philipp A. Kim, Yong-Jin Lin, Fay Maffei, Erica Pontone, Gianluca Raff, Gilbert L. Shaw, Leslee J. Villines, Todd C. Dunning, Allison Min, James K. |
author_sort | Ahmadi, Amir |
collection | PubMed |
description | Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p<0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p>0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p=0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p=0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome. |
format | Online Article Text |
id | pubmed-4348482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43484822015-03-06 Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) Ahmadi, Amir Leipsic, Jonathon Feuchtner, Gudrun Gransar, Heidi Kalra, Dan Heo, Ran Achenbach, Stephan Andreini, Daniele Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Chinnaiyan, Kavitha Chow, Benjamin Cury, Ricardo C. Delago, Augustin Gomez, Millie J. Hadamitzky, Martin Hausleiter, Joerg Hindoyan, Niree Kaufmann, Philipp A. Kim, Yong-Jin Lin, Fay Maffei, Erica Pontone, Gianluca Raff, Gilbert L. Shaw, Leslee J. Villines, Todd C. Dunning, Allison Min, James K. PLoS One Research Article Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p<0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p>0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p=0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p=0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome. Public Library of Science 2015-03-03 /pmc/articles/PMC4348482/ /pubmed/25734639 http://dx.doi.org/10.1371/journal.pone.0118998 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Ahmadi, Amir Leipsic, Jonathon Feuchtner, Gudrun Gransar, Heidi Kalra, Dan Heo, Ran Achenbach, Stephan Andreini, Daniele Al-Mallah, Mouaz Berman, Daniel S. Budoff, Matthew Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Chinnaiyan, Kavitha Chow, Benjamin Cury, Ricardo C. Delago, Augustin Gomez, Millie J. Hadamitzky, Martin Hausleiter, Joerg Hindoyan, Niree Kaufmann, Philipp A. Kim, Yong-Jin Lin, Fay Maffei, Erica Pontone, Gianluca Raff, Gilbert L. Shaw, Leslee J. Villines, Todd C. Dunning, Allison Min, James K. Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) |
title | Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) |
title_full | Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) |
title_fullStr | Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) |
title_full_unstemmed | Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) |
title_short | Is Metabolic Syndrome Predictive of Prevalence, Extent, and Risk of Coronary Artery Disease beyond Its Components? Results from the Multinational Coronary CT Angiography Evaluation for Clinical Outcome: An International Multicenter Registry (CONFIRM) |
title_sort | is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome: an international multicenter registry (confirm) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348482/ https://www.ncbi.nlm.nih.gov/pubmed/25734639 http://dx.doi.org/10.1371/journal.pone.0118998 |
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