CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans

BACKGROUND: Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5(+) B lymphocytes, which results in a progressive failure of the immune system. Despite intense research efforts, drug resistance remains a major cause of treatment...

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Detalles Bibliográficos
Autores principales: Martinez-Torres, Ana-Carolina, Quiney, Claire, Attout, Tarik, Boullet, Heloïse, Herbi, Linda, Vela, Laura, Barbier, Sandrine, Chateau, Danielle, Chapiro, Elise, Nguyen-Khac, Florence, Davi, Frédéric, Le Garff-Tavernier, Magali, Moumné, Roba, Sarfati, Marika, Karoyan, Philippe, Merle-Béral, Hélène, Launay, Pierre, Susin, Santos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348493/
https://www.ncbi.nlm.nih.gov/pubmed/25734483
http://dx.doi.org/10.1371/journal.pmed.1001796

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