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Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry

OBJECTIVES: Stereotactic body radiotherapy (SBRT) is a definitive local treatment option for patients with stage I non-small cell lung cancer (NSCLC) who are not surgical candidates and patients who refuse surgery. The purpose of this study was to assess the impact of SBRT on T1–T2 NSCLC from a nati...

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Autores principales: Davis, Joanne N., Medbery, Clinton, Sharma, Sanjeev, Perry, David, Pablo, John, D’Ambrosio, David J., McKellar, Heidi, Kimsey, Frank C., Chomiak, Paul N., Mahadevan, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348495/
https://www.ncbi.nlm.nih.gov/pubmed/25774243
http://dx.doi.org/10.1007/s13566-014-0177-0
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author Davis, Joanne N.
Medbery, Clinton
Sharma, Sanjeev
Perry, David
Pablo, John
D’Ambrosio, David J.
McKellar, Heidi
Kimsey, Frank C.
Chomiak, Paul N.
Mahadevan, Anand
author_facet Davis, Joanne N.
Medbery, Clinton
Sharma, Sanjeev
Perry, David
Pablo, John
D’Ambrosio, David J.
McKellar, Heidi
Kimsey, Frank C.
Chomiak, Paul N.
Mahadevan, Anand
author_sort Davis, Joanne N.
collection PubMed
description OBJECTIVES: Stereotactic body radiotherapy (SBRT) is a definitive local treatment option for patients with stage I non-small cell lung cancer (NSCLC) who are not surgical candidates and patients who refuse surgery. The purpose of this study was to assess the impact of SBRT on T1–T2 NSCLC from a national registry, reflecting practices and outcomes in a real-world setting. METHODS: The RSSearch® Patient Registry was screened for T1–T2N0M0 NSCLC patients treated from May 2004 to May 2013 with SBRT. Descriptive analyses were used for patient, tumor, and treatment characteristics. Overall survival (OS) and local control (LC) were calculated using the Kaplan-Meier method. RESULTS: In total, 723 patients with 517 T1 and 224 T2 lesions were treated with SBRT. Median follow-up was 12 months (1–87 months) with a median age of 76 years. Median SBRT dose was 54 Gy (range 10–80 Gy) delivered in a median of 3 fractions (range 1–5), and median biological equivalent dose (BED(10)) was 151.2 Gy (range 20–240 Gy). Median OS was 30 and 26 months for T1 and T2 tumors, respectively (p = 0.019). LC was associated with higher BED(10) for T2 tumors, but not in T1 tumors at a median follow-up of 17 months. Seventeen-month LC for T2 tumors treated with BED(10) < 105 Gy, BED(10) 105-149, and BED(10) ≥ 150 Gy was 43, 74, and 95 %, respectively (p = 0.011). Local failure rates for T2 tumors treated with BED(10) < 105 Gy, 105–149 Gy, and ≥150 Gy were 32, 21, and 8 % (p = 0.029), respectively. Median OS for patients with T2 tumors treated with BED(10) < 105 Gy was 17 vs. 32 months for T2 tumors treated with BED(10) 105–149 Gy (p = 0.062). CONCLUSION: SBRT for T1–T2 NSCLC is feasible and effective in the community setting. OS was greater for patients with T1 lesions compared to T2 lesions. An improvement in LC was observed in patients with T2 lesions treated with BED(10) > 105 Gy.
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spelling pubmed-43484952015-03-11 Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry Davis, Joanne N. Medbery, Clinton Sharma, Sanjeev Perry, David Pablo, John D’Ambrosio, David J. McKellar, Heidi Kimsey, Frank C. Chomiak, Paul N. Mahadevan, Anand J Radiat Oncol Original Research OBJECTIVES: Stereotactic body radiotherapy (SBRT) is a definitive local treatment option for patients with stage I non-small cell lung cancer (NSCLC) who are not surgical candidates and patients who refuse surgery. The purpose of this study was to assess the impact of SBRT on T1–T2 NSCLC from a national registry, reflecting practices and outcomes in a real-world setting. METHODS: The RSSearch® Patient Registry was screened for T1–T2N0M0 NSCLC patients treated from May 2004 to May 2013 with SBRT. Descriptive analyses were used for patient, tumor, and treatment characteristics. Overall survival (OS) and local control (LC) were calculated using the Kaplan-Meier method. RESULTS: In total, 723 patients with 517 T1 and 224 T2 lesions were treated with SBRT. Median follow-up was 12 months (1–87 months) with a median age of 76 years. Median SBRT dose was 54 Gy (range 10–80 Gy) delivered in a median of 3 fractions (range 1–5), and median biological equivalent dose (BED(10)) was 151.2 Gy (range 20–240 Gy). Median OS was 30 and 26 months for T1 and T2 tumors, respectively (p = 0.019). LC was associated with higher BED(10) for T2 tumors, but not in T1 tumors at a median follow-up of 17 months. Seventeen-month LC for T2 tumors treated with BED(10) < 105 Gy, BED(10) 105-149, and BED(10) ≥ 150 Gy was 43, 74, and 95 %, respectively (p = 0.011). Local failure rates for T2 tumors treated with BED(10) < 105 Gy, 105–149 Gy, and ≥150 Gy were 32, 21, and 8 % (p = 0.029), respectively. Median OS for patients with T2 tumors treated with BED(10) < 105 Gy was 17 vs. 32 months for T2 tumors treated with BED(10) 105–149 Gy (p = 0.062). CONCLUSION: SBRT for T1–T2 NSCLC is feasible and effective in the community setting. OS was greater for patients with T1 lesions compared to T2 lesions. An improvement in LC was observed in patients with T2 lesions treated with BED(10) > 105 Gy. Springer Berlin Heidelberg 2015-01-31 2015 /pmc/articles/PMC4348495/ /pubmed/25774243 http://dx.doi.org/10.1007/s13566-014-0177-0 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Research
Davis, Joanne N.
Medbery, Clinton
Sharma, Sanjeev
Perry, David
Pablo, John
D’Ambrosio, David J.
McKellar, Heidi
Kimsey, Frank C.
Chomiak, Paul N.
Mahadevan, Anand
Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
title Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
title_full Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
title_fullStr Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
title_full_unstemmed Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
title_short Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry
title_sort stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a national patient registry
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348495/
https://www.ncbi.nlm.nih.gov/pubmed/25774243
http://dx.doi.org/10.1007/s13566-014-0177-0
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