Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis

OBJECTIVE: Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. METHODS: Whole blood, CD4+ and CD8+ T cell DNA from 16 female, treatment naïve MS patients and 14 matched controls was profiled using the HumanMethy...

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Detalles Bibliográficos
Autores principales: Bos, Steffan D., Page, Christian M., Andreassen, Bettina K., Elboudwarej, Emon, Gustavsen, Marte W., Briggs, Farren, Quach, Hong, Leikfoss, Ingvild S., Bjølgerud, Anja, Berge, Tone, Harbo, Hanne F., Barcellos, Lisa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348521/
https://www.ncbi.nlm.nih.gov/pubmed/25734800
http://dx.doi.org/10.1371/journal.pone.0117403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348521/
https://www.ncbi.nlm.nih.gov/pubmed/25734800
http://dx.doi.org/10.1371/journal.pone.0117403

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