Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity

There is a desperate need for targeted therapeutic interventions that slow the progression of amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compartments that span both the central and peripheral...

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Detalles Bibliográficos
Autores principales: Blizzard, Catherine A., Southam, Katherine A., Dawkins, Edgar, Lewis, Katherine E., King, Anna E., Clark, Jayden A., Dickson, Tracey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348560/
https://www.ncbi.nlm.nih.gov/pubmed/25740331
http://dx.doi.org/10.1242/dmm.018606

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