A novel GAA-repeat-expansion-based mouse model of Friedreich’s ataxia

Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a GAA repeat expansion mutation within intron 1 of the FXN gene, resulting in reduced levels of frataxin protein. We have previously reported the generation of human FXN yeast artificial chromosome (YAC) transg...

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Detalles Bibliográficos
Autores principales: Anjomani Virmouni, Sara, Ezzatizadeh, Vahid, Sandi, Chiranjeevi, Sandi, Madhavi, Al-Mahdawi, Sahar, Chutake, Yogesh, Pook, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348561/
https://www.ncbi.nlm.nih.gov/pubmed/25681319
http://dx.doi.org/10.1242/dmm.018952

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