Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy

Anaplastic thyroid carcinoma (ATC) although rare is the most lethal form of thyroid cancer. The mortality rate for ATC is very high, with a median survival time of only 5 months; the survival rate at 1 year after diagnosis is <20%. Management of ATC is extremely difficult and rife with uncertaint...

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Autores principales: Abe, Ichiro, Karasaki, Satoko, Matsuda, Yayoi, Sakamoto, Shohei, Nakashima, Torahiko, Yamamoto, Hidetaka, Kawate, Hisaya, Ohnaka, Keizo, Nakashima, Hisashi, Kobayashi, Kunihisa, Oda, Yoshinao, Nomura, Masatoshi, Takayanagi, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348586/
https://www.ncbi.nlm.nih.gov/pubmed/25789182
http://dx.doi.org/10.1155/2015/726085
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author Abe, Ichiro
Karasaki, Satoko
Matsuda, Yayoi
Sakamoto, Shohei
Nakashima, Torahiko
Yamamoto, Hidetaka
Kawate, Hisaya
Ohnaka, Keizo
Nakashima, Hisashi
Kobayashi, Kunihisa
Oda, Yoshinao
Nomura, Masatoshi
Takayanagi, Ryoichi
author_facet Abe, Ichiro
Karasaki, Satoko
Matsuda, Yayoi
Sakamoto, Shohei
Nakashima, Torahiko
Yamamoto, Hidetaka
Kawate, Hisaya
Ohnaka, Keizo
Nakashima, Hisashi
Kobayashi, Kunihisa
Oda, Yoshinao
Nomura, Masatoshi
Takayanagi, Ryoichi
author_sort Abe, Ichiro
collection PubMed
description Anaplastic thyroid carcinoma (ATC) although rare is the most lethal form of thyroid cancer. The mortality rate for ATC is very high, with a median survival time of only 5 months; the survival rate at 1 year after diagnosis is <20%. Management of ATC is extremely difficult and rife with uncertainties. Herein, we describe a 75-year-old woman who presented with ATC and was successfully treated using concomitant treatment with docetaxel and high-dose radiotherapy. This case appears to be the first to have been reported in the literature involving complete remission of ATC confirmed by autopsy, suggesting the therapeutic potential of this combination.
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spelling pubmed-43485862015-03-18 Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy Abe, Ichiro Karasaki, Satoko Matsuda, Yayoi Sakamoto, Shohei Nakashima, Torahiko Yamamoto, Hidetaka Kawate, Hisaya Ohnaka, Keizo Nakashima, Hisashi Kobayashi, Kunihisa Oda, Yoshinao Nomura, Masatoshi Takayanagi, Ryoichi Case Rep Endocrinol Case Report Anaplastic thyroid carcinoma (ATC) although rare is the most lethal form of thyroid cancer. The mortality rate for ATC is very high, with a median survival time of only 5 months; the survival rate at 1 year after diagnosis is <20%. Management of ATC is extremely difficult and rife with uncertainties. Herein, we describe a 75-year-old woman who presented with ATC and was successfully treated using concomitant treatment with docetaxel and high-dose radiotherapy. This case appears to be the first to have been reported in the literature involving complete remission of ATC confirmed by autopsy, suggesting the therapeutic potential of this combination. Hindawi Publishing Corporation 2015 2015-02-18 /pmc/articles/PMC4348586/ /pubmed/25789182 http://dx.doi.org/10.1155/2015/726085 Text en Copyright © 2015 Ichiro Abe et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Abe, Ichiro
Karasaki, Satoko
Matsuda, Yayoi
Sakamoto, Shohei
Nakashima, Torahiko
Yamamoto, Hidetaka
Kawate, Hisaya
Ohnaka, Keizo
Nakashima, Hisashi
Kobayashi, Kunihisa
Oda, Yoshinao
Nomura, Masatoshi
Takayanagi, Ryoichi
Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy
title Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy
title_full Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy
title_fullStr Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy
title_full_unstemmed Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy
title_short Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy
title_sort complete remission of anaplastic thyroid carcinoma after concomitant treatment with docetaxel and radiotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348586/
https://www.ncbi.nlm.nih.gov/pubmed/25789182
http://dx.doi.org/10.1155/2015/726085
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