Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry

Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of pept...

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Detalles Bibliográficos
Autores principales: Weiß, Frederik, Schnabel, Anke, Planatscher, Hannes, van den Berg, Bart H. J., Serschnitzki, Bettina, Nuessler, Andreas K., Thasler, Wolfgang E., Weiss, Thomas S., Reuss, Matthias, Stoll, Dieter, Templin, Markus F., Joos, Thomas O., Marcus, Katrin, Poetz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348618/
https://www.ncbi.nlm.nih.gov/pubmed/25737130
http://dx.doi.org/10.1038/srep08759

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