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Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas
Melanoma is an aggressive neoplasm, and early diagnosis can reduce mortality in such patients. Diagnosis may be delayed in amelanotic tumors. We present one such case, a 35-year-old lady with a rapidly growing mass over the right angle of mandible. Fine-needle aspiration cytology was done, and smear...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349013/ https://www.ncbi.nlm.nih.gov/pubmed/25745288 http://dx.doi.org/10.4103/0970-9371.151134 |
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author | Mondal, Santosh Kumar Mondal, Palash Kumar Dutta, Sujit Kumar |
author_facet | Mondal, Santosh Kumar Mondal, Palash Kumar Dutta, Sujit Kumar |
author_sort | Mondal, Santosh Kumar |
collection | PubMed |
description | Melanoma is an aggressive neoplasm, and early diagnosis can reduce mortality in such patients. Diagnosis may be delayed in amelanotic tumors. We present one such case, a 35-year-old lady with a rapidly growing mass over the right angle of mandible. Fine-needle aspiration cytology was done, and smears showed discretely arranged large epithelioid cells with high N:C ratio, prominent single to multiple nucleoli. Occasional binucleated and multinucleated tumor giant cells were also noted. Poorly differentiated carcinoma, high-grade non-Hodgkin lymphoma, amelanotic melanoma, and pleomorphic sarcoma were included as differential diagnoses. Immunocytochemistry (ICC) revealed Melan-A/MART-1 positivity in some cells and S-100 positivity in most tumor cells. Desmin, pancytokeratin, and leukocyte common antigen were negative. Based on cytomorphological features and ICC findings, a diagnosis of epithelioid variant of amelanotic melanoma was rendered. Later on, true cut biopsy and histologic examination of excised specimen and adjunct immunohistochemistry with positive Melan-A and S-100 confirmed the diagnosis. |
format | Online Article Text |
id | pubmed-4349013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43490132015-03-05 Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas Mondal, Santosh Kumar Mondal, Palash Kumar Dutta, Sujit Kumar J Cytol Case Report Melanoma is an aggressive neoplasm, and early diagnosis can reduce mortality in such patients. Diagnosis may be delayed in amelanotic tumors. We present one such case, a 35-year-old lady with a rapidly growing mass over the right angle of mandible. Fine-needle aspiration cytology was done, and smears showed discretely arranged large epithelioid cells with high N:C ratio, prominent single to multiple nucleoli. Occasional binucleated and multinucleated tumor giant cells were also noted. Poorly differentiated carcinoma, high-grade non-Hodgkin lymphoma, amelanotic melanoma, and pleomorphic sarcoma were included as differential diagnoses. Immunocytochemistry (ICC) revealed Melan-A/MART-1 positivity in some cells and S-100 positivity in most tumor cells. Desmin, pancytokeratin, and leukocyte common antigen were negative. Based on cytomorphological features and ICC findings, a diagnosis of epithelioid variant of amelanotic melanoma was rendered. Later on, true cut biopsy and histologic examination of excised specimen and adjunct immunohistochemistry with positive Melan-A and S-100 confirmed the diagnosis. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4349013/ /pubmed/25745288 http://dx.doi.org/10.4103/0970-9371.151134 Text en Copyright: © Journal of Cytology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Mondal, Santosh Kumar Mondal, Palash Kumar Dutta, Sujit Kumar Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
title | Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
title_full | Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
title_fullStr | Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
title_full_unstemmed | Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
title_short | Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
title_sort | cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349013/ https://www.ncbi.nlm.nih.gov/pubmed/25745288 http://dx.doi.org/10.4103/0970-9371.151134 |
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