NKG2D Ligands in Tumor Immunity: Two Sides of a Coin

The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8(+) T, and subsets of γδ(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role o...

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Detalles Bibliográficos
Autores principales: Zhang, Jinyu, Basher, Fahmin, Wu, Jennifer D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349182/
https://www.ncbi.nlm.nih.gov/pubmed/25788898
http://dx.doi.org/10.3389/fimmu.2015.00097
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author Zhang, Jinyu
Basher, Fahmin
Wu, Jennifer D.
author_facet Zhang, Jinyu
Basher, Fahmin
Wu, Jennifer D.
author_sort Zhang, Jinyu
collection PubMed
description The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8(+) T, and subsets of γδ(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and cancer prognosis had been controversial in the literature. In this review, we summarize the latest advancement, discuss the controversies, and present evidence that membrane-bound and soluble NKG2D ligands oppositely regulate tumor immunity. We also discuss new perspectives of targeting NKG2D ligands for cancer immunotherapy.
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spelling pubmed-43491822015-03-18 NKG2D Ligands in Tumor Immunity: Two Sides of a Coin Zhang, Jinyu Basher, Fahmin Wu, Jennifer D. Front Immunol Immunology The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8(+) T, and subsets of γδ(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and cancer prognosis had been controversial in the literature. In this review, we summarize the latest advancement, discuss the controversies, and present evidence that membrane-bound and soluble NKG2D ligands oppositely regulate tumor immunity. We also discuss new perspectives of targeting NKG2D ligands for cancer immunotherapy. Frontiers Media S.A. 2015-03-04 /pmc/articles/PMC4349182/ /pubmed/25788898 http://dx.doi.org/10.3389/fimmu.2015.00097 Text en Copyright © 2015 Zhang, Basher and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Jinyu
Basher, Fahmin
Wu, Jennifer D.
NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
title NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
title_full NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
title_fullStr NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
title_full_unstemmed NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
title_short NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
title_sort nkg2d ligands in tumor immunity: two sides of a coin
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349182/
https://www.ncbi.nlm.nih.gov/pubmed/25788898
http://dx.doi.org/10.3389/fimmu.2015.00097
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