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Beneficial effects of varicocele embolization on semen parameters

BACKGROUND: The value of varicocele repair and the latter's impact on semen parameters are still subject to debate. METHODS: We analyse changes over time in initially abnormal sperm parameters and serum concentrations of testosterone, FSH and inhibin B after embolization treatment of males with...

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Autores principales: Prasivoravong, Julie, Marcelli, François, Lemaître, Laurent, Pigny, Pascal, Ramdane, Nassima, Peers, Marie-Claire, Mitchell, Valérie, Rigot, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349315/
https://www.ncbi.nlm.nih.gov/pubmed/25780583
http://dx.doi.org/10.1186/2051-4190-24-9
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author Prasivoravong, Julie
Marcelli, François
Lemaître, Laurent
Pigny, Pascal
Ramdane, Nassima
Peers, Marie-Claire
Mitchell, Valérie
Rigot, Jean-Marc
author_facet Prasivoravong, Julie
Marcelli, François
Lemaître, Laurent
Pigny, Pascal
Ramdane, Nassima
Peers, Marie-Claire
Mitchell, Valérie
Rigot, Jean-Marc
author_sort Prasivoravong, Julie
collection PubMed
description BACKGROUND: The value of varicocele repair and the latter's impact on semen parameters are still subject to debate. METHODS: We analyse changes over time in initially abnormal sperm parameters and serum concentrations of testosterone, FSH and inhibin B after embolization treatment of males with high-grade varicocele. From 2007 to 2012, we recruited 47 male infertile patients with clinically visible left varicocele in the resting patient and at least one abnormal semen parameter. Sperm parameters and serum levels of total testosterone, FSH and inhibin B were measured prior to retrograde embolization (M0) and then 3 (M3) and 6 (M6) months afterwards. RESULTS: At M0, the median sperm concentration was 5.78 [0.84-37.70] × 10(6)/ejaculate. The mean ± SD sperm progressive motility, vitality and percentage of normal sperm were respectively, 21.83 ± 16.48%, 61.88 ± 15.98% and 12.88 ± 7.15%. The corresponding values at M3 were significantly higher (38.75 [3.96-95] × 10(6)/ejaculate, 29.32 ± 14.21%, 69.14 ± 14.86% and 19.03 ± 11.02%, respectively). The mean percentage of spermatozoa with a thin head was significantly lower at M6 (6.35 ± 5.29%) than at M0 (14.03 ± 13.09%). The mean serum testosterone, FSH and inhibin B levels did not change significantly over time. CONCLUSIONS: Embolization treatment in men with clinically visible left varicocele, abnormal sperm parameters and documented infertility is associated with a significant improvement in semen parameters including sperm head morphology.
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spelling pubmed-43493152015-03-16 Beneficial effects of varicocele embolization on semen parameters Prasivoravong, Julie Marcelli, François Lemaître, Laurent Pigny, Pascal Ramdane, Nassima Peers, Marie-Claire Mitchell, Valérie Rigot, Jean-Marc Basic Clin Androl Research Article BACKGROUND: The value of varicocele repair and the latter's impact on semen parameters are still subject to debate. METHODS: We analyse changes over time in initially abnormal sperm parameters and serum concentrations of testosterone, FSH and inhibin B after embolization treatment of males with high-grade varicocele. From 2007 to 2012, we recruited 47 male infertile patients with clinically visible left varicocele in the resting patient and at least one abnormal semen parameter. Sperm parameters and serum levels of total testosterone, FSH and inhibin B were measured prior to retrograde embolization (M0) and then 3 (M3) and 6 (M6) months afterwards. RESULTS: At M0, the median sperm concentration was 5.78 [0.84-37.70] × 10(6)/ejaculate. The mean ± SD sperm progressive motility, vitality and percentage of normal sperm were respectively, 21.83 ± 16.48%, 61.88 ± 15.98% and 12.88 ± 7.15%. The corresponding values at M3 were significantly higher (38.75 [3.96-95] × 10(6)/ejaculate, 29.32 ± 14.21%, 69.14 ± 14.86% and 19.03 ± 11.02%, respectively). The mean percentage of spermatozoa with a thin head was significantly lower at M6 (6.35 ± 5.29%) than at M0 (14.03 ± 13.09%). The mean serum testosterone, FSH and inhibin B levels did not change significantly over time. CONCLUSIONS: Embolization treatment in men with clinically visible left varicocele, abnormal sperm parameters and documented infertility is associated with a significant improvement in semen parameters including sperm head morphology. BioMed Central 2014-05-16 /pmc/articles/PMC4349315/ /pubmed/25780583 http://dx.doi.org/10.1186/2051-4190-24-9 Text en © Prasivoravong et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Prasivoravong, Julie
Marcelli, François
Lemaître, Laurent
Pigny, Pascal
Ramdane, Nassima
Peers, Marie-Claire
Mitchell, Valérie
Rigot, Jean-Marc
Beneficial effects of varicocele embolization on semen parameters
title Beneficial effects of varicocele embolization on semen parameters
title_full Beneficial effects of varicocele embolization on semen parameters
title_fullStr Beneficial effects of varicocele embolization on semen parameters
title_full_unstemmed Beneficial effects of varicocele embolization on semen parameters
title_short Beneficial effects of varicocele embolization on semen parameters
title_sort beneficial effects of varicocele embolization on semen parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349315/
https://www.ncbi.nlm.nih.gov/pubmed/25780583
http://dx.doi.org/10.1186/2051-4190-24-9
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