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Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53
Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TM...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349320/ https://www.ncbi.nlm.nih.gov/pubmed/25756342 http://dx.doi.org/10.1186/s13567-015-0162-7 |
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author | Clawson, Michael L Redden, Reid Schuller, Gennie Heaton, Michael P Workman, Aspen Chitko-McKown, Carol G Smith, Timothy PL Leymaster, Kreg A |
author_facet | Clawson, Michael L Redden, Reid Schuller, Gennie Heaton, Michael P Workman, Aspen Chitko-McKown, Carol G Smith, Timothy PL Leymaster, Kreg A |
author_sort | Clawson, Michael L |
collection | PubMed |
description | Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. In this study, a novel SRLV subgroup was identified that naturally infected sheep with various TMEM154 diplotypes, including those homozygous for a rare frameshift mutation (A4 delta53), which is predicted to abolish TMEM154 protein function. Thus, these SRLVs may infect sheep that lack functional TMEM154, and may not be restricted by TMEM154 diplotypes in establishing infections. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-015-0162-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4349320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43493202015-03-05 Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 Clawson, Michael L Redden, Reid Schuller, Gennie Heaton, Michael P Workman, Aspen Chitko-McKown, Carol G Smith, Timothy PL Leymaster, Kreg A Vet Res Short Report Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. In this study, a novel SRLV subgroup was identified that naturally infected sheep with various TMEM154 diplotypes, including those homozygous for a rare frameshift mutation (A4 delta53), which is predicted to abolish TMEM154 protein function. Thus, these SRLVs may infect sheep that lack functional TMEM154, and may not be restricted by TMEM154 diplotypes in establishing infections. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-015-0162-7) contains supplementary material, which is available to authorized users. BioMed Central 2015-03-05 2015 /pmc/articles/PMC4349320/ /pubmed/25756342 http://dx.doi.org/10.1186/s13567-015-0162-7 Text en © Clawson et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Clawson, Michael L Redden, Reid Schuller, Gennie Heaton, Michael P Workman, Aspen Chitko-McKown, Carol G Smith, Timothy PL Leymaster, Kreg A Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 |
title | Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 |
title_full | Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 |
title_fullStr | Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 |
title_full_unstemmed | Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 |
title_short | Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53 |
title_sort | genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for tmem154 frameshift deletion mutation a4(δ)53 |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349320/ https://www.ncbi.nlm.nih.gov/pubmed/25756342 http://dx.doi.org/10.1186/s13567-015-0162-7 |
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