Complex Interaction of Deferasirox and Pythium insidiosum: Iron-Dependent Attenuation of Growth In Vitro and Immunotherapy-Like Enhancement of Immune Responses In Vivo

Pythium insidiosum iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity in vitro and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to P. insidiosum hyphae in vitro, but that activity is diminished in...

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Detalles Bibliográficos
Autores principales: Zanette, Régis A., Bitencourt, Paula E. R., Kontoyiannis, Dimitrios P., Fighera, Rafael A., Flores, Mariana M., Kommers, Glaucia D., Silva, Priscila S., Ludwig, Aline, Moretto, Maria B., Alves, Sydney H., Santurio, Janio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349436/
https://www.ncbi.nlm.nih.gov/pubmed/25738758
http://dx.doi.org/10.1371/journal.pone.0118932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349436/
https://www.ncbi.nlm.nih.gov/pubmed/25738758
http://dx.doi.org/10.1371/journal.pone.0118932

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