Endogenous Interferon-β-Inducible Gene Expression and Interferon-β-Treatment Are Associated with Reduced T Cell Responses to Myelin Basic Protein in Multiple Sclerosis

Autoreactive CD4(+) T-cells are considered to play a major role in the pathogenesis of multiple sclerosis. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, exogenous and endogenous type I interferons restrict disease severity. Recombinant interferon-β is used for...

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Detalles Bibliográficos
Autores principales: Börnsen, Lars, Romme Christensen, Jeppe, Ratzer, Rikke, Hedegaard, Chris, Søndergaard, Helle B., Krakauer, Martin, Hesse, Dan, Nielsen, Claus H., Sorensen, Per S., Sellebjerg, Finn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349448/
https://www.ncbi.nlm.nih.gov/pubmed/25738751
http://dx.doi.org/10.1371/journal.pone.0118830

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