Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 amino acid sequenced difference but quite diffe...

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Detalles Bibliográficos
Autores principales: Zhan, Cheng, Yan, Li, Wang, Lin, Ma, Jun, Jiang, Wei, Zhang, Yongxing, Shi, Yu, Wang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349452/
https://www.ncbi.nlm.nih.gov/pubmed/25738776
http://dx.doi.org/10.1371/journal.pone.0118663

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