Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

INTRODUCTION: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examined human lung tissue from 40 subjects with defined smoking status, with or wit...

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Detalles Bibliográficos
Autores principales: Lugli, Elena B, Correia, Raquel ESM, Fischer, Roman, Lundberg, Karin, Bracke, Ken R, Montgomery, Anna B, Kessler, Benedikt M, Brusselle, Guy G, Venables, Patrick J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349479/
https://www.ncbi.nlm.nih.gov/pubmed/25600626
http://dx.doi.org/10.1186/s13075-015-0520-x

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