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Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study

BACKGROUND: Correlations among Chiari type II malformation (CMII) morphological findings, the proportion of fetal heart rate patterns corresponding to the quiet phase (QP), and neurological outcomes have yet to be investigated. FINDINGS: The correlations among the morphological findings (i.e., the d...

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Autores principales: Otera, Yuka, Morokuma, Seiichi, Fukushima, Kotaro, Anami, Ai, Yumoto, Yasuo, Ito, Yushi, Ochiai, Masayuki, Hashiguchi, Kimiaki, Wake, Norio, Sago, Haruhiko, Kato, Kiyoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349618/
https://www.ncbi.nlm.nih.gov/pubmed/25890237
http://dx.doi.org/10.1186/s13104-015-1014-2
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author Otera, Yuka
Morokuma, Seiichi
Fukushima, Kotaro
Anami, Ai
Yumoto, Yasuo
Ito, Yushi
Ochiai, Masayuki
Hashiguchi, Kimiaki
Wake, Norio
Sago, Haruhiko
Kato, Kiyoko
author_facet Otera, Yuka
Morokuma, Seiichi
Fukushima, Kotaro
Anami, Ai
Yumoto, Yasuo
Ito, Yushi
Ochiai, Masayuki
Hashiguchi, Kimiaki
Wake, Norio
Sago, Haruhiko
Kato, Kiyoko
author_sort Otera, Yuka
collection PubMed
description BACKGROUND: Correlations among Chiari type II malformation (CMII) morphological findings, the proportion of fetal heart rate patterns corresponding to the quiet phase (QP), and neurological outcomes have yet to be investigated. FINDINGS: The correlations among the morphological findings (i.e., the degree of ventriculomegaly, myelomeningocele levels, and degree of cerebellar herniation), proportion of time spent in QP, and developmental quotients (DQs) were analyzed in 22 children. The proportion of time spent in QP was compared between children with poor neurological outcomes (n = 9) and those with good outcomes (n = 13). Pearson’s correlations and the Mann–Whitney U-test were used to assess for statistical significance; P < 0.05 was considered statistically significant. No significant differences were observed between the DQs and morphological findings, but the DQs and the proportion of time spent in QP were significantly correlated (r = 0.287, P = 0.01). The proportion of time spent in QP was significantly different between children with poor outcomes and those with good outcomes (median, 11% [range, 0–32%] vs. 28% [range, 2–55%]; P = 0.006). CONCLUSIONS: The proportion of fetal heart rate patterns corresponding to the QP might be a useful predictor of neurological outcomes in 2-year-old children with CMII.
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spelling pubmed-43496182015-03-05 Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study Otera, Yuka Morokuma, Seiichi Fukushima, Kotaro Anami, Ai Yumoto, Yasuo Ito, Yushi Ochiai, Masayuki Hashiguchi, Kimiaki Wake, Norio Sago, Haruhiko Kato, Kiyoko BMC Res Notes Short Report BACKGROUND: Correlations among Chiari type II malformation (CMII) morphological findings, the proportion of fetal heart rate patterns corresponding to the quiet phase (QP), and neurological outcomes have yet to be investigated. FINDINGS: The correlations among the morphological findings (i.e., the degree of ventriculomegaly, myelomeningocele levels, and degree of cerebellar herniation), proportion of time spent in QP, and developmental quotients (DQs) were analyzed in 22 children. The proportion of time spent in QP was compared between children with poor neurological outcomes (n = 9) and those with good outcomes (n = 13). Pearson’s correlations and the Mann–Whitney U-test were used to assess for statistical significance; P < 0.05 was considered statistically significant. No significant differences were observed between the DQs and morphological findings, but the DQs and the proportion of time spent in QP were significantly correlated (r = 0.287, P = 0.01). The proportion of time spent in QP was significantly different between children with poor outcomes and those with good outcomes (median, 11% [range, 0–32%] vs. 28% [range, 2–55%]; P = 0.006). CONCLUSIONS: The proportion of fetal heart rate patterns corresponding to the QP might be a useful predictor of neurological outcomes in 2-year-old children with CMII. BioMed Central 2015-02-27 /pmc/articles/PMC4349618/ /pubmed/25890237 http://dx.doi.org/10.1186/s13104-015-1014-2 Text en © Otera et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public DomainDedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Otera, Yuka
Morokuma, Seiichi
Fukushima, Kotaro
Anami, Ai
Yumoto, Yasuo
Ito, Yushi
Ochiai, Masayuki
Hashiguchi, Kimiaki
Wake, Norio
Sago, Haruhiko
Kato, Kiyoko
Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
title Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
title_full Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
title_fullStr Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
title_full_unstemmed Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
title_short Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
title_sort neurological outcomes in chiari type ii malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349618/
https://www.ncbi.nlm.nih.gov/pubmed/25890237
http://dx.doi.org/10.1186/s13104-015-1014-2
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