The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca(2+)-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study

BACKGROUND: Calmodulin (CaM) plays an important role in Ca(2+)-dependent signal transduction. Ca(2+) binding to CaM triggers a conformational change, forming a hydrophobic patch that is important for target protein recognition. CaM regulates a Ca(2+)-dependent inactivation process in store-operated...

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Detalles Bibliográficos
Autores principales: Jensen, Drake, Reynolds, Nicole, Yang, Ya-Ping, Shakya, Shubha, Wang, Zhi-Qiang, Stuehr, Dennis J, Wei, Chin-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349623/
https://www.ncbi.nlm.nih.gov/pubmed/25888318
http://dx.doi.org/10.1186/s12858-015-0036-7

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