In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; their antiplasmodial action in rodent malaria model

BACKGROUND: Emergence of drug-resistant parasite strains has surfaced as a major obstacle in attempts to ameliorate malaria. Current treatment regimen of malaria relies on the concept of artemisinin-based combination therapy (ACT). METHODS: Fluoroquinolone analogues, compounds 10, 12 and 18 were inv...

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Detalles Bibliográficos
Autores principales: Agarwal, Drishti, Sharma, Manish, Dixit, Sandeep K, Dutta, Roshan K, Singh, Ashok K, Gupta, Rinkoo D, Awasthi, Satish K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349624/
https://www.ncbi.nlm.nih.gov/pubmed/25652883
http://dx.doi.org/10.1186/s12936-015-0561-2

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