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Correlates of a single cortical action potential in the epidural EEG

To identify the correlates of a single cortical action potential in surface EEG, we recorded simultaneously epidural EEG and single-unit activity in the primary somatosensory cortex of awake macaque monkeys. By averaging over EEG segments coincident with more than hundred thousand single spikes, we...

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Detalles Bibliográficos
Autores principales: Teleńczuk, Bartosz, Baker, Stuart N, Kempter, Richard, Curio, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349634/
https://www.ncbi.nlm.nih.gov/pubmed/25554430
http://dx.doi.org/10.1016/j.neuroimage.2014.12.057
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author Teleńczuk, Bartosz
Baker, Stuart N
Kempter, Richard
Curio, Gabriel
author_facet Teleńczuk, Bartosz
Baker, Stuart N
Kempter, Richard
Curio, Gabriel
author_sort Teleńczuk, Bartosz
collection PubMed
description To identify the correlates of a single cortical action potential in surface EEG, we recorded simultaneously epidural EEG and single-unit activity in the primary somatosensory cortex of awake macaque monkeys. By averaging over EEG segments coincident with more than hundred thousand single spikes, we found short-lived (≈ 0.5 ms) triphasic EEG deflections dominated by high-frequency components > 800 Hz. The peak-to-peak amplitude of the grand-averaged spike correlate was 80 nV, which matched theoretical predictions, while single-neuron amplitudes ranged from 12 to 966 nV. Combining these estimates with post-stimulus-time histograms of single-unit responses to median-nerve stimulation allowed us to predict the shape of the evoked epidural EEG response and to estimate the number of contributing neurons. These findings establish spiking activity of cortical neurons as a primary building block of high-frequency epidural EEG, which thus can serve as a quantitative macroscopic marker of neuronal spikes.
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spelling pubmed-43496342015-04-01 Correlates of a single cortical action potential in the epidural EEG Teleńczuk, Bartosz Baker, Stuart N Kempter, Richard Curio, Gabriel Neuroimage Article To identify the correlates of a single cortical action potential in surface EEG, we recorded simultaneously epidural EEG and single-unit activity in the primary somatosensory cortex of awake macaque monkeys. By averaging over EEG segments coincident with more than hundred thousand single spikes, we found short-lived (≈ 0.5 ms) triphasic EEG deflections dominated by high-frequency components > 800 Hz. The peak-to-peak amplitude of the grand-averaged spike correlate was 80 nV, which matched theoretical predictions, while single-neuron amplitudes ranged from 12 to 966 nV. Combining these estimates with post-stimulus-time histograms of single-unit responses to median-nerve stimulation allowed us to predict the shape of the evoked epidural EEG response and to estimate the number of contributing neurons. These findings establish spiking activity of cortical neurons as a primary building block of high-frequency epidural EEG, which thus can serve as a quantitative macroscopic marker of neuronal spikes. Academic Press 2015-04-01 /pmc/articles/PMC4349634/ /pubmed/25554430 http://dx.doi.org/10.1016/j.neuroimage.2014.12.057 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Teleńczuk, Bartosz
Baker, Stuart N
Kempter, Richard
Curio, Gabriel
Correlates of a single cortical action potential in the epidural EEG
title Correlates of a single cortical action potential in the epidural EEG
title_full Correlates of a single cortical action potential in the epidural EEG
title_fullStr Correlates of a single cortical action potential in the epidural EEG
title_full_unstemmed Correlates of a single cortical action potential in the epidural EEG
title_short Correlates of a single cortical action potential in the epidural EEG
title_sort correlates of a single cortical action potential in the epidural eeg
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349634/
https://www.ncbi.nlm.nih.gov/pubmed/25554430
http://dx.doi.org/10.1016/j.neuroimage.2014.12.057
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