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Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan

BACKGROUND: Fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD), a rapidly emerging and widely recognized liver disease today, is regarded as a hepatic manifestation of metabolic syndrome. Helicobacter pylori, one of the most common pathogens worldwide, has been reported to...

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Autores principales: Okushin, Kazuya, Takahashi, Yu, Yamamichi, Nobutake, Shimamoto, Takeshi, Enooku, Kenichiro, Fujinaga, Hidetaka, Tsutsumi, Takeya, Shintani, Yoshizumi, Sakaguchi, Yoshiki, Ono, Satoshi, Kodashima, Shinya, Fujishiro, Mitsuhiro, Moriya, Kyoji, Yotsuyanagi, Hiroshi, Mitsushima, Toru, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349671/
https://www.ncbi.nlm.nih.gov/pubmed/25880912
http://dx.doi.org/10.1186/s12876-015-0247-9
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author Okushin, Kazuya
Takahashi, Yu
Yamamichi, Nobutake
Shimamoto, Takeshi
Enooku, Kenichiro
Fujinaga, Hidetaka
Tsutsumi, Takeya
Shintani, Yoshizumi
Sakaguchi, Yoshiki
Ono, Satoshi
Kodashima, Shinya
Fujishiro, Mitsuhiro
Moriya, Kyoji
Yotsuyanagi, Hiroshi
Mitsushima, Toru
Koike, Kazuhiko
author_facet Okushin, Kazuya
Takahashi, Yu
Yamamichi, Nobutake
Shimamoto, Takeshi
Enooku, Kenichiro
Fujinaga, Hidetaka
Tsutsumi, Takeya
Shintani, Yoshizumi
Sakaguchi, Yoshiki
Ono, Satoshi
Kodashima, Shinya
Fujishiro, Mitsuhiro
Moriya, Kyoji
Yotsuyanagi, Hiroshi
Mitsushima, Toru
Koike, Kazuhiko
author_sort Okushin, Kazuya
collection PubMed
description BACKGROUND: Fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD), a rapidly emerging and widely recognized liver disease today, is regarded as a hepatic manifestation of metabolic syndrome. Helicobacter pylori, one of the most common pathogens worldwide, has been reported to be associated with metabolic syndrome, but whether there is a direct association with FLD is as of yet unclear. The aim of this study was to clarify the association of FLD and NAFLD with causative background factors including Helicobacter pylori infection. METHODS: This was a cross-sectional study of Japanese adults who received medical checkups at a single medical center in 2010.Univariate and multivariate statistical analysis was performed to evaluate background factors for ultrasonography diagnosed FLD. Subjects free from alcohol influence were similarly analyzed for NAFLD. RESULTS: Of a total of 13,737 subjects, FLD was detected in 1,456 of 6,318 females (23.0 %) and 3,498 of 7,419 males (47.1%). Multivariable analyses revealed that body mass index (standardized coefficients of females and males (β-F/M) =143.5/102.5), serum ALT (β-F/M = 25.8/75.7), age (β-F/M = 34.3/17.2), and platelet count (β-F/M = 17.8/15.2) were positively associated with FLD in both genders. Of the 5,289 subjects free from alcohol influence, NAFLD was detected in 881 of 3,473 females (25.4%) and 921 of 1,816 males (50.7%). Body mass index (β-F/M = 113.3/55.3), serum ALT (β-F/M = 21.6/53.8), and platelet count (β-F/M = 13.8/11.8) were positively associated with NAFLD in both genders. Metabolic syndrome was positively associated with FLD and NAFLD only in males. In contrast, Helicobacter pylori infection status was neither associated with FLD nor NAFLD regardless of gender. CONCLUSIONS: Body mass index, serum ALT and platelet count were significantly associated with FLD and NAFLD, whereas infection of Helicobacter pylori was not. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12876-015-0247-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-43496712015-03-05 Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan Okushin, Kazuya Takahashi, Yu Yamamichi, Nobutake Shimamoto, Takeshi Enooku, Kenichiro Fujinaga, Hidetaka Tsutsumi, Takeya Shintani, Yoshizumi Sakaguchi, Yoshiki Ono, Satoshi Kodashima, Shinya Fujishiro, Mitsuhiro Moriya, Kyoji Yotsuyanagi, Hiroshi Mitsushima, Toru Koike, Kazuhiko BMC Gastroenterol Research Article BACKGROUND: Fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD), a rapidly emerging and widely recognized liver disease today, is regarded as a hepatic manifestation of metabolic syndrome. Helicobacter pylori, one of the most common pathogens worldwide, has been reported to be associated with metabolic syndrome, but whether there is a direct association with FLD is as of yet unclear. The aim of this study was to clarify the association of FLD and NAFLD with causative background factors including Helicobacter pylori infection. METHODS: This was a cross-sectional study of Japanese adults who received medical checkups at a single medical center in 2010.Univariate and multivariate statistical analysis was performed to evaluate background factors for ultrasonography diagnosed FLD. Subjects free from alcohol influence were similarly analyzed for NAFLD. RESULTS: Of a total of 13,737 subjects, FLD was detected in 1,456 of 6,318 females (23.0 %) and 3,498 of 7,419 males (47.1%). Multivariable analyses revealed that body mass index (standardized coefficients of females and males (β-F/M) =143.5/102.5), serum ALT (β-F/M = 25.8/75.7), age (β-F/M = 34.3/17.2), and platelet count (β-F/M = 17.8/15.2) were positively associated with FLD in both genders. Of the 5,289 subjects free from alcohol influence, NAFLD was detected in 881 of 3,473 females (25.4%) and 921 of 1,816 males (50.7%). Body mass index (β-F/M = 113.3/55.3), serum ALT (β-F/M = 21.6/53.8), and platelet count (β-F/M = 13.8/11.8) were positively associated with NAFLD in both genders. Metabolic syndrome was positively associated with FLD and NAFLD only in males. In contrast, Helicobacter pylori infection status was neither associated with FLD nor NAFLD regardless of gender. CONCLUSIONS: Body mass index, serum ALT and platelet count were significantly associated with FLD and NAFLD, whereas infection of Helicobacter pylori was not. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12876-015-0247-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-19 /pmc/articles/PMC4349671/ /pubmed/25880912 http://dx.doi.org/10.1186/s12876-015-0247-9 Text en © Okushin et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Okushin, Kazuya
Takahashi, Yu
Yamamichi, Nobutake
Shimamoto, Takeshi
Enooku, Kenichiro
Fujinaga, Hidetaka
Tsutsumi, Takeya
Shintani, Yoshizumi
Sakaguchi, Yoshiki
Ono, Satoshi
Kodashima, Shinya
Fujishiro, Mitsuhiro
Moriya, Kyoji
Yotsuyanagi, Hiroshi
Mitsushima, Toru
Koike, Kazuhiko
Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan
title Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan
title_full Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan
title_fullStr Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan
title_full_unstemmed Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan
title_short Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan
title_sort helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in japan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349671/
https://www.ncbi.nlm.nih.gov/pubmed/25880912
http://dx.doi.org/10.1186/s12876-015-0247-9
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