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Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters
BACKGROUND: Aging is associated with physiological or pathological left ventricular hypertrophy (LVH) cardiac changes. Secondhand smoke (SHS) exposure is associated with pathological LVH. The action mechanism in cardiac concentric hypertrophy from SHS exposure is understood, but the transition contr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349676/ https://www.ncbi.nlm.nih.gov/pubmed/25524239 http://dx.doi.org/10.1186/1471-2261-14-195 |
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author | Wu, Jia-Ping Hsieh, Cheng-Hong Ho, Tsung-Jung Kuo, Wei-Wen Yeh, Yu-Lan Lin, Chien-Chung Kuo, Chia-Hua Huang, Chih-Yang |
author_facet | Wu, Jia-Ping Hsieh, Cheng-Hong Ho, Tsung-Jung Kuo, Wei-Wen Yeh, Yu-Lan Lin, Chien-Chung Kuo, Chia-Hua Huang, Chih-Yang |
author_sort | Wu, Jia-Ping |
collection | PubMed |
description | BACKGROUND: Aging is associated with physiological or pathological left ventricular hypertrophy (LVH) cardiac changes. Secondhand smoke (SHS) exposure is associated with pathological LVH. The action mechanism in cardiac concentric hypertrophy from SHS exposure is understood, but the transition contributed from SHS exposure is not. To determine whether exposure to SHS has an impact on age-induced LVH we examined young and old hamsters that underwent SHS exposure in a chamber for 30 mins. METHODS: Morphological and histological studies were then conducted using hematoxylin and eosin (H&E) and Masson’s trichrome staining. Echocardiographic analysis was used to determine left ventricular wall thickness and function. LVH related protein expression levels were detected by western blot analysis. RESULTS: The results showed that both young and aged hamsters exposed to SHS exhibited increased heart weights and left ventricular weights, left ventricular posterior wall thickness and intraventricular septum systolic and diastolic pressure also increased. However, left ventricular function systolic and diastolic pressure deteriorated. H&E and Masson’s trichrome staining results showed LV papillary muscles were ruptured, resulting in lower cardiac function at the myocardial level. LV muscle fiber arrangement was disordered and collagen accumulation occurred. Concentric LVH related protein molecular markers increased only in young hamsters exposed to SHS. However, this declined with hamster age. By contrast, eccentric LVH related proteins increased in aging hamsters exposed the SHS. Pro-inflammatory proteins, IL-6, TNF-α, JAK1, STAT3, and SIRTI expression increased in aging hamsters exposed to SHS. CONCLUSIONS: We suggest that SHS exposure induces a pro-inflammatory response that results in concentric transition to aging eccentric LVH. |
format | Online Article Text |
id | pubmed-4349676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43496762015-03-05 Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters Wu, Jia-Ping Hsieh, Cheng-Hong Ho, Tsung-Jung Kuo, Wei-Wen Yeh, Yu-Lan Lin, Chien-Chung Kuo, Chia-Hua Huang, Chih-Yang BMC Cardiovasc Disord Research Article BACKGROUND: Aging is associated with physiological or pathological left ventricular hypertrophy (LVH) cardiac changes. Secondhand smoke (SHS) exposure is associated with pathological LVH. The action mechanism in cardiac concentric hypertrophy from SHS exposure is understood, but the transition contributed from SHS exposure is not. To determine whether exposure to SHS has an impact on age-induced LVH we examined young and old hamsters that underwent SHS exposure in a chamber for 30 mins. METHODS: Morphological and histological studies were then conducted using hematoxylin and eosin (H&E) and Masson’s trichrome staining. Echocardiographic analysis was used to determine left ventricular wall thickness and function. LVH related protein expression levels were detected by western blot analysis. RESULTS: The results showed that both young and aged hamsters exposed to SHS exhibited increased heart weights and left ventricular weights, left ventricular posterior wall thickness and intraventricular septum systolic and diastolic pressure also increased. However, left ventricular function systolic and diastolic pressure deteriorated. H&E and Masson’s trichrome staining results showed LV papillary muscles were ruptured, resulting in lower cardiac function at the myocardial level. LV muscle fiber arrangement was disordered and collagen accumulation occurred. Concentric LVH related protein molecular markers increased only in young hamsters exposed to SHS. However, this declined with hamster age. By contrast, eccentric LVH related proteins increased in aging hamsters exposed the SHS. Pro-inflammatory proteins, IL-6, TNF-α, JAK1, STAT3, and SIRTI expression increased in aging hamsters exposed to SHS. CONCLUSIONS: We suggest that SHS exposure induces a pro-inflammatory response that results in concentric transition to aging eccentric LVH. BioMed Central 2014-12-19 /pmc/articles/PMC4349676/ /pubmed/25524239 http://dx.doi.org/10.1186/1471-2261-14-195 Text en © Wu et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wu, Jia-Ping Hsieh, Cheng-Hong Ho, Tsung-Jung Kuo, Wei-Wen Yeh, Yu-Lan Lin, Chien-Chung Kuo, Chia-Hua Huang, Chih-Yang Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
title | Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
title_full | Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
title_fullStr | Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
title_full_unstemmed | Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
title_short | Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
title_sort | secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349676/ https://www.ncbi.nlm.nih.gov/pubmed/25524239 http://dx.doi.org/10.1186/1471-2261-14-195 |
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