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Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
BACKGROUND: The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. CASE PRESENTATION: Here, we described the clinical presentations, muscle biopsy studies a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349692/ https://www.ncbi.nlm.nih.gov/pubmed/25884435 http://dx.doi.org/10.1186/s12883-015-0275-7 |
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author | Matsuura, Eiji Yoshimura, Akiko Nozuma, Satoshi Higuchi, Itsuro Kubota, Ryuji Takashima, Hiroshi |
author_facet | Matsuura, Eiji Yoshimura, Akiko Nozuma, Satoshi Higuchi, Itsuro Kubota, Ryuji Takashima, Hiroshi |
author_sort | Matsuura, Eiji |
collection | PubMed |
description | BACKGROUND: The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. CASE PRESENTATION: Here, we described the clinical presentations, muscle biopsy studies and laboratory results of two siblings with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) who were affected with lumbar lordosis. Computed tomography (CT) scans demonstrated marked paraspinal muscle atrophy in both patients. Immunohistochemical studies of biopsy tissue obtained from one of the patients revealed inflammatory change of the muscle. Upon oral prednisolone therapy, the patient showed improvement in muscle strength and serum creatine kinase (CK) level. CONCLUSION: Myopathy or specifically axial myopathy should be considered as clinical symptom when treating the patients with HTLV-1 infection. |
format | Online Article Text |
id | pubmed-4349692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43496922015-03-05 Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) Matsuura, Eiji Yoshimura, Akiko Nozuma, Satoshi Higuchi, Itsuro Kubota, Ryuji Takashima, Hiroshi BMC Neurol Case Report BACKGROUND: The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. CASE PRESENTATION: Here, we described the clinical presentations, muscle biopsy studies and laboratory results of two siblings with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) who were affected with lumbar lordosis. Computed tomography (CT) scans demonstrated marked paraspinal muscle atrophy in both patients. Immunohistochemical studies of biopsy tissue obtained from one of the patients revealed inflammatory change of the muscle. Upon oral prednisolone therapy, the patient showed improvement in muscle strength and serum creatine kinase (CK) level. CONCLUSION: Myopathy or specifically axial myopathy should be considered as clinical symptom when treating the patients with HTLV-1 infection. BioMed Central 2015-02-28 /pmc/articles/PMC4349692/ /pubmed/25884435 http://dx.doi.org/10.1186/s12883-015-0275-7 Text en © Matsuura et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Matsuura, Eiji Yoshimura, Akiko Nozuma, Satoshi Higuchi, Itsuro Kubota, Ryuji Takashima, Hiroshi Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
title | Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
title_full | Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
title_fullStr | Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
title_full_unstemmed | Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
title_short | Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) |
title_sort | clinical presentation of axial myopathy in two siblings with htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp) |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349692/ https://www.ncbi.nlm.nih.gov/pubmed/25884435 http://dx.doi.org/10.1186/s12883-015-0275-7 |
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