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Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

BACKGROUND: The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. CASE PRESENTATION: Here, we described the clinical presentations, muscle biopsy studies a...

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Autores principales: Matsuura, Eiji, Yoshimura, Akiko, Nozuma, Satoshi, Higuchi, Itsuro, Kubota, Ryuji, Takashima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349692/
https://www.ncbi.nlm.nih.gov/pubmed/25884435
http://dx.doi.org/10.1186/s12883-015-0275-7
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author Matsuura, Eiji
Yoshimura, Akiko
Nozuma, Satoshi
Higuchi, Itsuro
Kubota, Ryuji
Takashima, Hiroshi
author_facet Matsuura, Eiji
Yoshimura, Akiko
Nozuma, Satoshi
Higuchi, Itsuro
Kubota, Ryuji
Takashima, Hiroshi
author_sort Matsuura, Eiji
collection PubMed
description BACKGROUND: The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. CASE PRESENTATION: Here, we described the clinical presentations, muscle biopsy studies and laboratory results of two siblings with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) who were affected with lumbar lordosis. Computed tomography (CT) scans demonstrated marked paraspinal muscle atrophy in both patients. Immunohistochemical studies of biopsy tissue obtained from one of the patients revealed inflammatory change of the muscle. Upon oral prednisolone therapy, the patient showed improvement in muscle strength and serum creatine kinase (CK) level. CONCLUSION: Myopathy or specifically axial myopathy should be considered as clinical symptom when treating the patients with HTLV-1 infection.
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spelling pubmed-43496922015-03-05 Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) Matsuura, Eiji Yoshimura, Akiko Nozuma, Satoshi Higuchi, Itsuro Kubota, Ryuji Takashima, Hiroshi BMC Neurol Case Report BACKGROUND: The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. CASE PRESENTATION: Here, we described the clinical presentations, muscle biopsy studies and laboratory results of two siblings with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) who were affected with lumbar lordosis. Computed tomography (CT) scans demonstrated marked paraspinal muscle atrophy in both patients. Immunohistochemical studies of biopsy tissue obtained from one of the patients revealed inflammatory change of the muscle. Upon oral prednisolone therapy, the patient showed improvement in muscle strength and serum creatine kinase (CK) level. CONCLUSION: Myopathy or specifically axial myopathy should be considered as clinical symptom when treating the patients with HTLV-1 infection. BioMed Central 2015-02-28 /pmc/articles/PMC4349692/ /pubmed/25884435 http://dx.doi.org/10.1186/s12883-015-0275-7 Text en © Matsuura et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Matsuura, Eiji
Yoshimura, Akiko
Nozuma, Satoshi
Higuchi, Itsuro
Kubota, Ryuji
Takashima, Hiroshi
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
title Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
title_full Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
title_fullStr Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
title_full_unstemmed Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
title_short Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
title_sort clinical presentation of axial myopathy in two siblings with htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349692/
https://www.ncbi.nlm.nih.gov/pubmed/25884435
http://dx.doi.org/10.1186/s12883-015-0275-7
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