The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

AIMS: We recently published that the positive inotropic response (PIR) to levosimendan can be fully accounted for by phosphodiesterase (PDE) inhibition in both failing human heart and normal rat heart. To determine if the PIR of the active metabolite OR-1896, an important mediator of the long-term c...

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Detalles Bibliográficos
Autores principales: Ørstavik, Øivind, Manfra, Ornella, Andressen, Kjetil Wessel, Andersen, Geir Øystein, Skomedal, Tor, Osnes, Jan-Bjørn, Levy, Finn Olav, Krobert, Kurt Allen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349697/
https://www.ncbi.nlm.nih.gov/pubmed/25738589
http://dx.doi.org/10.1371/journal.pone.0115547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349697/
https://www.ncbi.nlm.nih.gov/pubmed/25738589
http://dx.doi.org/10.1371/journal.pone.0115547

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