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RNA: a possible contributor to the 'missing heritability’
A number of human pathologies have a transmission pattern that does not obey Mendelian segregation rules. This type of heredity is defined as non-Mendelian and is based on mechanisms of transgenerational epigenetic inheritance. Comprehensive information on the molecular mechanisms of it is still lac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349726/ https://www.ncbi.nlm.nih.gov/pubmed/25780571 http://dx.doi.org/10.1186/2051-4190-23-9 |
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author | Grandjean, Valérie Badro, Danielle A Kiani, Jafar |
author_facet | Grandjean, Valérie Badro, Danielle A Kiani, Jafar |
author_sort | Grandjean, Valérie |
collection | PubMed |
description | A number of human pathologies have a transmission pattern that does not obey Mendelian segregation rules. This type of heredity is defined as non-Mendelian and is based on mechanisms of transgenerational epigenetic inheritance. Comprehensive information on the molecular mechanisms of it is still lacking. However, recent evidence from distantly related species including Caenorhabditis elegans, Drosophila, and mouse, points towards a role for non-coding RNA molecules in such a pattern of inheritance. While it would be too hasty to conclude that RNA molecules are at work in the transgenerational non-genetic inheritance of human pathologies, a growing number of studies seem to strongly support such a speculation. |
format | Online Article Text |
id | pubmed-4349726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43497262015-03-16 RNA: a possible contributor to the 'missing heritability’ Grandjean, Valérie Badro, Danielle A Kiani, Jafar Basic Clin Androl Review Article A number of human pathologies have a transmission pattern that does not obey Mendelian segregation rules. This type of heredity is defined as non-Mendelian and is based on mechanisms of transgenerational epigenetic inheritance. Comprehensive information on the molecular mechanisms of it is still lacking. However, recent evidence from distantly related species including Caenorhabditis elegans, Drosophila, and mouse, points towards a role for non-coding RNA molecules in such a pattern of inheritance. While it would be too hasty to conclude that RNA molecules are at work in the transgenerational non-genetic inheritance of human pathologies, a growing number of studies seem to strongly support such a speculation. BioMed Central 2013-11-01 /pmc/articles/PMC4349726/ /pubmed/25780571 http://dx.doi.org/10.1186/2051-4190-23-9 Text en © Grandjean et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Grandjean, Valérie Badro, Danielle A Kiani, Jafar RNA: a possible contributor to the 'missing heritability’ |
title | RNA: a possible contributor to the 'missing heritability’ |
title_full | RNA: a possible contributor to the 'missing heritability’ |
title_fullStr | RNA: a possible contributor to the 'missing heritability’ |
title_full_unstemmed | RNA: a possible contributor to the 'missing heritability’ |
title_short | RNA: a possible contributor to the 'missing heritability’ |
title_sort | rna: a possible contributor to the 'missing heritability’ |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349726/ https://www.ncbi.nlm.nih.gov/pubmed/25780571 http://dx.doi.org/10.1186/2051-4190-23-9 |
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