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A Predictive In Vitro Model of the Impact of Drugs with Anticholinergic Properties on Human Neuronal and Astrocytic Systems
The link between off-target anticholinergic effects of medications and acute cognitive impairment in older adults requires urgent investigation. We aimed to determine whether a relevant in vitro model may aid the identification of anticholinergic responses to drugs and the prediction of anticholiner...
Autores principales: | Woehrling, Elizabeth K., Parri, H. Rheinallt, Tse, Erin H. Y., Hill, Eric J., Maidment, Ian D., Fox, G. Christopher, Coleman, Michael D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349811/ https://www.ncbi.nlm.nih.gov/pubmed/25738989 http://dx.doi.org/10.1371/journal.pone.0118786 |
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