Cargando…
Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma
Carbonic anhydrase IX (CA-IX), a hypoxia marker, correlates with tumor progression in a variety of human cancers. However, the role of CA-IX in hepatocellular carcinomas (HCCs) remains largely unknown. We examined the expression of 277 unifocal, resectable, primary HCC tumors using immunohistochemis...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349857/ https://www.ncbi.nlm.nih.gov/pubmed/25738958 http://dx.doi.org/10.1371/journal.pone.0119181 |
_version_ | 1782360095815892992 |
---|---|
author | Huang, Wei-Ju Jeng, Yung-Ming Lai, Hong-Shiee Fong, Iok-U Sheu, Fang-Yu Bonnie Lai, Po-Lin Yuan, Ray-Hwang |
author_facet | Huang, Wei-Ju Jeng, Yung-Ming Lai, Hong-Shiee Fong, Iok-U Sheu, Fang-Yu Bonnie Lai, Po-Lin Yuan, Ray-Hwang |
author_sort | Huang, Wei-Ju |
collection | PubMed |
description | Carbonic anhydrase IX (CA-IX), a hypoxia marker, correlates with tumor progression in a variety of human cancers. However, the role of CA-IX in hepatocellular carcinomas (HCCs) remains largely unknown. We examined the expression of 277 unifocal, resectable, primary HCC tumors using immunohistochemistry. The CA-IX protein was expressed in 110 of the 227 (48.5%) HCC tumors. The expression of CA-IX correlated with younger age (P = 0.0446), female sex (P = 0.0049), high serum α-fetoprotein levels (P<1x10(-6)), larger tumor size (P = 0.0031), high tumor grade P<1x10(-6)) and high tumor stage (P = 1.5x10(-6)). Patients with HCC tumors that expressed CA-IX were more likely to have lower 5-year disease-free survival (DFS; P = 0.0001) and 5-year overall survival (OS; P<1x10(-6)). The multivariate analysis indicated that CA-IX expression was an independent predictor for high tumor stage (P = 0.0047) and DFS (P = 0.0456), and a borderline predictor for OS (P = 0.0762). Furthermore, CA-IX expression predicted poor DFS and OS in patients with high tumor stage (P = 0.0004 and P<1x10(-6), respectively). Interestingly, CA-IX expression might contribute to the worse prognosis of female patients with advanced HCCs. Our study indicates the expression of the CA-IX protein is a crucial predictor of poor prognosis in resectable HCC, and it is also an unfavorable prognostic predictor in HCC patients with high tumor stage. |
format | Online Article Text |
id | pubmed-4349857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43498572015-03-17 Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma Huang, Wei-Ju Jeng, Yung-Ming Lai, Hong-Shiee Fong, Iok-U Sheu, Fang-Yu Bonnie Lai, Po-Lin Yuan, Ray-Hwang PLoS One Research Article Carbonic anhydrase IX (CA-IX), a hypoxia marker, correlates with tumor progression in a variety of human cancers. However, the role of CA-IX in hepatocellular carcinomas (HCCs) remains largely unknown. We examined the expression of 277 unifocal, resectable, primary HCC tumors using immunohistochemistry. The CA-IX protein was expressed in 110 of the 227 (48.5%) HCC tumors. The expression of CA-IX correlated with younger age (P = 0.0446), female sex (P = 0.0049), high serum α-fetoprotein levels (P<1x10(-6)), larger tumor size (P = 0.0031), high tumor grade P<1x10(-6)) and high tumor stage (P = 1.5x10(-6)). Patients with HCC tumors that expressed CA-IX were more likely to have lower 5-year disease-free survival (DFS; P = 0.0001) and 5-year overall survival (OS; P<1x10(-6)). The multivariate analysis indicated that CA-IX expression was an independent predictor for high tumor stage (P = 0.0047) and DFS (P = 0.0456), and a borderline predictor for OS (P = 0.0762). Furthermore, CA-IX expression predicted poor DFS and OS in patients with high tumor stage (P = 0.0004 and P<1x10(-6), respectively). Interestingly, CA-IX expression might contribute to the worse prognosis of female patients with advanced HCCs. Our study indicates the expression of the CA-IX protein is a crucial predictor of poor prognosis in resectable HCC, and it is also an unfavorable prognostic predictor in HCC patients with high tumor stage. Public Library of Science 2015-03-04 /pmc/articles/PMC4349857/ /pubmed/25738958 http://dx.doi.org/10.1371/journal.pone.0119181 Text en © 2015 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Huang, Wei-Ju Jeng, Yung-Ming Lai, Hong-Shiee Fong, Iok-U Sheu, Fang-Yu Bonnie Lai, Po-Lin Yuan, Ray-Hwang Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma |
title | Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma |
title_full | Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma |
title_fullStr | Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma |
title_full_unstemmed | Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma |
title_short | Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma |
title_sort | expression of hypoxic marker carbonic anhydrase ix predicts poor prognosis in resectable hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349857/ https://www.ncbi.nlm.nih.gov/pubmed/25738958 http://dx.doi.org/10.1371/journal.pone.0119181 |
work_keys_str_mv | AT huangweiju expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma AT jengyungming expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma AT laihongshiee expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma AT fongioku expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma AT sheufangyubonnie expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma AT laipolin expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma AT yuanrayhwang expressionofhypoxicmarkercarbonicanhydraseixpredictspoorprognosisinresectablehepatocellularcarcinoma |