Human G3P[4] rotavirus obtained in Japan, 2013, possibly emerged through a human–equine rotavirus reassortment event

Two novel G3P[4] rotavirus strains were detected from children with acute diarrhea in Sendai, Japan, identified as a G3–P[4]–I2–R2–C2–M2–A2–N2–T2–E2–H2 genotype constellation by whole-genome sequence analysis. The VP7 gene of the two strains displayed the highest nucleotide sequence identity (91 %)...

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Detalles Bibliográficos
Autores principales: Malasao, Rungnapa, Saito, Mayuko, Suzuki, Akira, Imagawa, Toshifumi, Nukiwa-Soma, Nao, Tohma, Kentaro, Liu, Xiaofang, Okamoto, Michiko, Chaimongkol, Natthawan, Dapat, Clyde, Kawamura, Kazuhisa, Kayama, Yasuko, Masago, Yoshifumi, Omura, Tatsuo, Oshitani, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349953/
https://www.ncbi.nlm.nih.gov/pubmed/25352228
http://dx.doi.org/10.1007/s11262-014-1135-z
Descripción
Sumario:Two novel G3P[4] rotavirus strains were detected from children with acute diarrhea in Sendai, Japan, identified as a G3–P[4]–I2–R2–C2–M2–A2–N2–T2–E2–H2 genotype constellation by whole-genome sequence analysis. The VP7 gene of the two strains displayed the highest nucleotide sequence identity (91 %) and showed a close genetic relationship (99 % bootstrap value) to an equine rotavirus reported in India. The other gene segments were related to human group A rotaviruses. This report suggests a possible reassortment event between human and equine rotaviruses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11262-014-1135-z) contains supplementary material, which is available to authorized users.

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