Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

HLA class I molecules reflect the health state of cells to cytotoxic T cells by presenting a repertoire of endogenously derived peptides. However, the extent to which the proteome shapes the peptidome is still largely unknown. Here we present a high-throughput mass-spectrometry-based workflow that a...

Descripción completa

Detalles Bibliográficos
Autores principales: Bassani-Sternberg, Michal, Pletscher-Frankild, Sune, Jensen, Lars Juhl, Mann, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349985/
https://www.ncbi.nlm.nih.gov/pubmed/25576301
http://dx.doi.org/10.1074/mcp.M114.042812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349985/
https://www.ncbi.nlm.nih.gov/pubmed/25576301
http://dx.doi.org/10.1074/mcp.M114.042812

Ejemplares similares