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Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

HLA class I molecules reflect the health state of cells to cytotoxic T cells by presenting a repertoire of endogenously derived peptides. However, the extent to which the proteome shapes the peptidome is still largely unknown. Here we present a high-throughput mass-spectrometry-based workflow that a...

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Detalles Bibliográficos
Autores principales:	Bassani-Sternberg, Michal, Pletscher-Frankild, Sune, Jensen, Lars Juhl, Mann, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349985/ https://www.ncbi.nlm.nih.gov/pubmed/25576301 http://dx.doi.org/10.1074/mcp.M114.042812

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