Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors

Thalassospiramides comprise a large family of lipopeptide natural products produced by Thalassospira and Tistrella marine bacteria. Here we provide further evidence of their nanomolar inhibitory activity against the human calpain 1 protease. Analysis of structure-activity relationship data supported...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Liang, Meehan, Michael J., Gu, Shuo, Chen, Zhilong, Zhang, Weipeng, Zhang, Gen, Liu, Lingli, Huang, Xuhui, Dorrestein, Pieter C., Xu, Ying, Moore, Bradley S., Qian, Pei-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350077/
https://www.ncbi.nlm.nih.gov/pubmed/25740631
http://dx.doi.org/10.1038/srep08783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350077/
https://www.ncbi.nlm.nih.gov/pubmed/25740631
http://dx.doi.org/10.1038/srep08783

Ejemplares similares