Cargando…

Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors

Thalassospiramides comprise a large family of lipopeptide natural products produced by Thalassospira and Tistrella marine bacteria. Here we provide further evidence of their nanomolar inhibitory activity against the human calpain 1 protease. Analysis of structure-activity relationship data supported...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Liang, Meehan, Michael J., Gu, Shuo, Chen, Zhilong, Zhang, Weipeng, Zhang, Gen, Liu, Lingli, Huang, Xuhui, Dorrestein, Pieter C., Xu, Ying, Moore, Bradley S., Qian, Pei-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350077/ https://www.ncbi.nlm.nih.gov/pubmed/25740631 http://dx.doi.org/10.1038/srep08783

Ejemplares similares

Thalassospiramide G, a New γ-Amino-Acid-Bearing Peptide from the Marine Bacterium Thalassospira sp
por: Um, Soohyun, et al.
Publicado: (2013)

Conformationally restricted calpain inhibitors
por: Adams, S. E., et al.
Publicado: (2015)

Calpains in cyanobacteria and the origin of calpains
por: Vešelényiová, Dominika, et al.
Publicado: (2022)

Calpain-2 participates in the process of calpain-1 inactivation
por: Shinkai-Ouchi, Fumiko, et al.
Publicado: (2020)

Calpain-2 Inhibitors as Therapy for Traumatic Brain Injury
por: Baudry, Michel, et al.
Publicado: (2023)

Expression of calpain-like proteins and effects of calpain inhibitors on the growth rate of Angomonas deanei wild type and aposymbiotic strains
por: de Oliveira, Simone Santiago Carvalho, et al.
Publicado: (2015)

Bacterial calpains and the evolution of the calpain (C2) family of peptidases
por: Rawlings, Neil D.
Publicado: (2015)

Novel calpain families and novel mechanisms for calpain regulation in Aplysia
por: Hastings, Margaret H., et al.
Publicado: (2017)

Commentary on: Calpain-2 participates in the process of calpain-1 inactivation
por: Kumari, Raniki, et al.
Publicado: (2021)

Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death
por: Wang, Yubin, et al.
Publicado: (2020)

Antileishmanial activity of MDL 28170, a potent calpain inhibitor
por: d’Avila-Levy, Claudia M., et al.
Publicado: (2006)

Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy
por: Wang, Jinxi, et al.
Publicado: (2021)

Calpain-1 and Calpain-2 in the Brain: Dr. Jekill and Mr Hyde?
por: Baudry, Michel
Publicado: (2019)

Role of Calpain in Apoptosis
por: Momeni, Hamid Reza
Publicado: (2011)

Proteolytic inhibitors as alternative medicines to treat trypanosomatid-caused diseases: experience with calpain inhibitors
por: Ennes-Vidal, Vítor, et al.
Publicado: (2022)

Homology Modeling Study of Bovine μ-Calpain Inhibitor-Binding Domains
por: Chai, Han-Ha, et al.
Publicado: (2014)

Antileishmanial Efficacy of the Calpain Inhibitor MDL28170 in Combination with Amphotericin B
por: Branquinha, Marta H., et al.
Publicado: (2022)

Calpain 3 Is a Rapid-Action, Unidirectional Proteolytic Switch Central to Muscle Remodeling
por: de Morrée, Antoine, et al.
Publicado: (2010)

Calpain inhibitor nanocrystals prepared using Nano Spray Dryer B-90
por: Baba, Koichi, et al.
Publicado: (2012)

Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin
por: Nguyen, Hung Huy, et al.
Publicado: (2017)

Calpain Dysregulation in Alzheimer's Disease
por: Ferreira, Adriana
Publicado: (2012)

Role of Calpain-1 in Neurogenesis
por: Baudry, Michel, et al.
Publicado: (2021)

Calpain 8/nCL-2 and Calpain 9/nCL-4 Constitute an Active Protease Complex, G-Calpain, Involved in Gastric Mucosal Defense
por: Hata, Shoji, et al.
Publicado: (2010)

Calpain Activator Dibucaine Induces Platelet Apoptosis
por: Zhang, Weilin, et al.
Publicado: (2011)

Phosphorylation of Calpastatin Negatively Regulates the Activity of Calpain
por: Bai, Yuqiang, et al.
Publicado: (2023)

Targeted Capture and Heterologous Expression of the Pseudoalteromonas Alterochromide Gene Cluster in Escherichia coli Represents a Promising Natural Product Exploratory Platform
por: Ross, Avena C., et al.
Publicado: (2014)

Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development
por: Soh, Byoung Yul, et al.
Publicado: (2013)

Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice
por: Seinfeld, Jeff, et al.
Publicado: (2016)

The Calpain Inhibitor MDL28170 Induces the Expression of Apoptotic Markers in Leishmania amazonensis Promastigotes
por: Marinho, Fernanda A., et al.
Publicado: (2014)

A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells
por: Jang, Jaewoong, et al.
Publicado: (2017)

Class Action
Publicado: (1994)

The calpains: modular designs and functional diversity
por: Croall, Dorothy E, et al.
Publicado: (2007)

Calpain is required for macroautophagy in mammalian cells
por: Demarchi, Francesca, et al.
Publicado: (2006)

Regulatory role of calpain in neuronal death
por: Cheng, Si-ying, et al.
Publicado: (2018)

Involvement of calpain in the neuropathogenesis of Alzheimer’s disease
por: Mahaman, Yacoubou Abdoul Razak, et al.
Publicado: (2018)

Inhibition of Starvation-Triggered Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in ARPE-19 Cells by Taurine through Modulating the Expression of Calpain-1 and Calpain-2
por: Zhang, Yuanyuan, et al.
Publicado: (2017)

Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury
por: Zhang, Zifeng, et al.
Publicado: (2015)

Tissue-Specific Expression of the Chicken Calpain2 Gene
por: Zhang, Zeng-Rong, et al.
Publicado: (2010)

Calpain system protein expression and activity in ovarian cancer
por: Zhang, Siwei, et al.
Publicado: (2018)

MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes
por: Mailhes, John B, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_47q8dkumd25jittnfpn5i0bgjo