Substitution of tryptophan 89 with tyrosine switches the DNA binding mode of PC4

PC4, a well-known general transcription cofactor, has multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in PC4, but substituted by tyrosine in some PC4 orthologous proteins. In order to understand the consequences and reveal the molecular d...

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Detalles Bibliográficos
Autores principales: Huang, Jinguang, Zhao, Yanxiang, Liu, Huaian, Huang, Dan, Cheng, Xiankun, Zhao, Wensheng, Taylor, Ian A., Liu, Junfeng, Peng, You-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350104/
https://www.ncbi.nlm.nih.gov/pubmed/25739870
http://dx.doi.org/10.1038/srep08789

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