Cargando…
Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females
BACKGROUND: An unresolved question is the time required for the ability to return to complex tasks following anesthesia. OBJECTIVES: This study aims to characterize the severity and duration of cognitive impairment following sevoflurane or desfluane anesthesia after brief surgery using tests of cogn...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350164/ https://www.ncbi.nlm.nih.gov/pubmed/25789236 http://dx.doi.org/10.5812/aapm.22271 |
_version_ | 1782360147357597696 |
---|---|
author | Green, Michael S. Green, Parmis Neubert, Lee Voralu, Kirtanaa Saththasivam, Poovendran Mychaskiw, George |
author_facet | Green, Michael S. Green, Parmis Neubert, Lee Voralu, Kirtanaa Saththasivam, Poovendran Mychaskiw, George |
author_sort | Green, Michael S. |
collection | PubMed |
description | BACKGROUND: An unresolved question is the time required for the ability to return to complex tasks following anesthesia. OBJECTIVES: This study aims to characterize the severity and duration of cognitive impairment following sevoflurane or desfluane anesthesia after brief surgery using tests of cognitive ability to objectively testing performance. PATIENTS AND METHODS: This study is a double blinded randomized controlled trial. Patients were randomized to receive either a desflurane or sevoflurane-based anesthetic. On the morning of the surgery the subjects performed baseline cognitive task tests (Mini Mental Status exam, Trail Making Test Part A and B, Digit Symbol Coding, Hopkins Verbal Learning Test, Stroop Color and Word Test to determine baseline cognitive function. Cognitive testing was repeated 30 minutes and 1 hour after surgery whereas Modified Telephone Interview for Cognitive Status (TICS-M) and Memory Aging Telephone Screen (MATS) was used on the following day of surgery. RESULTS: Trail Making Test Part B cognitive test showed statistically significant in comparison for pre and post exposure of anesthetics. This difference was seen in the desflurane group. Other cognitive tests did not show differences on exposure to the anesthetic gases. CONCLUSIONS: This study questioned the difference between volatile anesthetic agent’s effects on patients completing a battery of neurocognitive tests attempting to answer if one agent has a more profound effect. Our study shows no statistically significant cognitive decline except for those in the Trail Making Part B in the Desflurane group. This conclusion is limited by the inherent limitations of the study, but does reinforce that the systemic inflammatory response from the surgery contributes cognitive impairment. |
format | Online Article Text |
id | pubmed-4350164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-43501642015-03-18 Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females Green, Michael S. Green, Parmis Neubert, Lee Voralu, Kirtanaa Saththasivam, Poovendran Mychaskiw, George Anesth Pain Med Research Article BACKGROUND: An unresolved question is the time required for the ability to return to complex tasks following anesthesia. OBJECTIVES: This study aims to characterize the severity and duration of cognitive impairment following sevoflurane or desfluane anesthesia after brief surgery using tests of cognitive ability to objectively testing performance. PATIENTS AND METHODS: This study is a double blinded randomized controlled trial. Patients were randomized to receive either a desflurane or sevoflurane-based anesthetic. On the morning of the surgery the subjects performed baseline cognitive task tests (Mini Mental Status exam, Trail Making Test Part A and B, Digit Symbol Coding, Hopkins Verbal Learning Test, Stroop Color and Word Test to determine baseline cognitive function. Cognitive testing was repeated 30 minutes and 1 hour after surgery whereas Modified Telephone Interview for Cognitive Status (TICS-M) and Memory Aging Telephone Screen (MATS) was used on the following day of surgery. RESULTS: Trail Making Test Part B cognitive test showed statistically significant in comparison for pre and post exposure of anesthetics. This difference was seen in the desflurane group. Other cognitive tests did not show differences on exposure to the anesthetic gases. CONCLUSIONS: This study questioned the difference between volatile anesthetic agent’s effects on patients completing a battery of neurocognitive tests attempting to answer if one agent has a more profound effect. Our study shows no statistically significant cognitive decline except for those in the Trail Making Part B in the Desflurane group. This conclusion is limited by the inherent limitations of the study, but does reinforce that the systemic inflammatory response from the surgery contributes cognitive impairment. Kowsar 2015-02-01 /pmc/articles/PMC4350164/ /pubmed/25789236 http://dx.doi.org/10.5812/aapm.22271 Text en Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Green, Michael S. Green, Parmis Neubert, Lee Voralu, Kirtanaa Saththasivam, Poovendran Mychaskiw, George Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females |
title | Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females |
title_full | Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females |
title_fullStr | Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females |
title_full_unstemmed | Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females |
title_short | Recovery Following Desflurane Versus Sevoflurane Anesthesia for Outpatient Urologic Surgery in Elderly Females |
title_sort | recovery following desflurane versus sevoflurane anesthesia for outpatient urologic surgery in elderly females |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350164/ https://www.ncbi.nlm.nih.gov/pubmed/25789236 http://dx.doi.org/10.5812/aapm.22271 |
work_keys_str_mv | AT greenmichaels recoveryfollowingdesfluraneversussevofluraneanesthesiaforoutpatienturologicsurgeryinelderlyfemales AT greenparmis recoveryfollowingdesfluraneversussevofluraneanesthesiaforoutpatienturologicsurgeryinelderlyfemales AT neubertlee recoveryfollowingdesfluraneversussevofluraneanesthesiaforoutpatienturologicsurgeryinelderlyfemales AT voralukirtanaa recoveryfollowingdesfluraneversussevofluraneanesthesiaforoutpatienturologicsurgeryinelderlyfemales AT saththasivampoovendran recoveryfollowingdesfluraneversussevofluraneanesthesiaforoutpatienturologicsurgeryinelderlyfemales AT mychaskiwgeorge recoveryfollowingdesfluraneversussevofluraneanesthesiaforoutpatienturologicsurgeryinelderlyfemales |