Cargando…

PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs

BACKGROUND: Membrane-associated ATP binding cassette (ABC) transport proteins hydrolyze ATP in order to translocate a broad spectrum of substrates, from single ions to macromolecules across membranes. In humans, members from this transport family have been linked to drug resistance phenotypes, e.g.,...

Descripción completa

Detalles Bibliográficos
Autores principales:	van der Velden, Maarten, Rijpma, Sanna R, Russel, Frans GM, Sauerwein, Robert W, Koenderink, Jan B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350286/ https://www.ncbi.nlm.nih.gov/pubmed/25884516 http://dx.doi.org/10.1186/s12936-015-0581-y

Ejemplares similares

Monitoring PfMDR1 transport in Plasmodium falciparum
por: Reiling, Sarah J, et al.
Publicado: (2015)

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
por: Kavishe, Reginald A, et al.
Publicado: (2009)

Assessment of Plasmodium falciparum PfMDR1 transport rates using Fluo-4
por: Friedrich, O, et al.
Publicado: (2014)

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum
por: Duvalsaint, Marvin, et al.
Publicado: (2021)

PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms
por: Ferreira, Pedro Eduardo, et al.
Publicado: (2011)

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
por: Eastman, Richard T., et al.
Publicado: (2016)

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
por: Veiga, M. Isabel, et al.
Publicado: (2016)

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport
por: Calçada, Carla, et al.
Publicado: (2020)

PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations
por: Simon, Nina, et al.
Publicado: (2022)

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1
por: Adjalley, Sophie H., et al.
Publicado: (2015)

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections
por: Pillai, Dylan R, et al.
Publicado: (2012)

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
por: Shafik, Sarah Heckmatt, et al.
Publicado: (2022)

Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy
por: Duah, Nancy O, et al.
Publicado: (2013)

Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity
por: Rijpma, Sanna R, et al.
Publicado: (2014)

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin
por: Njokah, Muturi J., et al.
Publicado: (2016)

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages
por: Ke, Hangjun, et al.
Publicado: (2019)

Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand
por: Mungthin, Mathirut, et al.
Publicado: (2014)

Rare mutations in Pfmdr1 gene of Plasmodium falciparum detected in clinical isolates from patients treated with anti-malarial drug in Nigeria
por: Idowu, Abel O., et al.
Publicado: (2019)

The Basal Complex Protein PfMORN1 Is Not Required for Asexual Replication of Plasmodium falciparum
por: Moran, Colleen J., et al.
Publicado: (2021)

Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum
por: Newby, Zachary E R, et al.
Publicado: (2008)

Molecular dynamics simulations of PfAQP from the malarial parasite Plasmodium falciparum
por: CUI, YUBAO, et al.
Publicado: (2012)

Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates
por: Dlamini, Sabelo V, et al.
Publicado: (2010)

Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China
por: Cheng, Weijia, et al.
Publicado: (2021)

Assessment of Plasmodium falciparum anti-malarial drug resistance markers in pfcrt and pfmdr1 genes in isolates from Honduras and Nicaragua, 2018–2021
por: Fontecha, Gustavo, et al.
Publicado: (2021)

K13 mutations and pfmdr1 copy number variation in Plasmodium falciparum malaria in Myanmar
por: Win, Aye A., et al.
Publicado: (2016)

Role of Different Pfcrt and Pfmdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum
por: Ibraheem, Zaid O., et al.
Publicado: (2014)

Essential function of alveolin PfIMC1g in the Plasmodium falciparum asexual blood stage
por: Cepeda Diaz, Ana Karla, et al.
Publicado: (2023)

Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen
por: Atroosh, Wahib M., et al.
Publicado: (2016)

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya
por: Muiruri, Peninah, et al.
Publicado: (2018)

Genetic polymorphisms in Plasmodium falciparum chloroquine resistance genes, pfcrt and pfmdr1, in North Sulawesi, Indonesia
por: Reteng, Patrick, et al.
Publicado: (2017)

Erratum to: K13 mutations and pfmdr1 copy number variation in Plasmodium falciparum malaria in Myanmar
por: Win, Aye A., et al.
Publicado: (2016)

Efficacy of Artemether-Lumefantrine on various Plasmodium falciparum Kelch 13 and Pfmdr1 genes isolated in Ghana
por: Aninagyei, Enoch, et al.
Publicado: (2020)

Molecular Surveillance of Pfkelch13 and Pfmdr1 Mutations in Plasmodium falciparum Isolates from Southern Thailand
por: Khammanee, Thunchanok, et al.
Publicado: (2019)

Epitope mapping of PfCP-2.9, an asexual blood-stage vaccine candidate of Plasmodium falciparum
por: Li, Changling, et al.
Publicado: (2010)

Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage of Plasmodium falciparum Asexual Maturation
por: Dahalan, Farah Aida, et al.
Publicado: (2016)

Prevalence of Plasmodium falciparum Pfcrt and Pfmdr1 alleles in settings with different levels of Plasmodium vivax co-endemicity in Ethiopia
por: Hailemeskel, Elifaged, et al.
Publicado: (2019)

Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy
por: Gadalla, Nahla B, et al.
Publicado: (2015)

A new method for detection of pfmdr1 mutations in Plasmodium falciparum DNA using real-time PCR
por: Purfield, Anne, et al.
Publicado: (2004)

Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum
por: Poyomtip, Teera, et al.
Publicado: (2012)

Dual fluorescent labelling of the human malaria parasite Plasmodium falciparum for the analysis of the ABC type transporter pfmdr2
por: Rosental, Benyamin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ig6s0j337c8l1db59mb2ucsudr