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Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors
BACKGROUND: Morphine-induced hyperalgesia and tolerance significantly limits its clinical use in relieving acute and chronic pain. Melatonin, a pineal gland neurohormone, has been shown to participate in certain neuropsychopharmacological actions. The present study investigated the effect of melaton...
Autores principales: | Song, Li, Wu, Chaoran, Zuo, Yunxia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350305/ https://www.ncbi.nlm.nih.gov/pubmed/25745356 http://dx.doi.org/10.1186/1471-2253-15-12 |
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