VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

Pyruvate dehydrogenase kinase (PDK) is a pivotal enzyme in cellular energy metabolism that has previously been implicated in cancer through both RNAi based studies and clinical correlations with poor prognosis in several cancer types. Here, we report the discovery of a novel and selective ATP compet...

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Detalles Bibliográficos
Autores principales: Moore, Jonathan D., Staniszewska, Anna, Shaw, Terence, D'Alessandro, Jalanie, Davis, Ben, Surgenor, Alan, Baker, Lisa, Matassova, Natalia, Murray, James, Macias, Alba, Brough, Paul, Wood, Mike, Mahon, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350332/
https://www.ncbi.nlm.nih.gov/pubmed/25404640

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