Cargando…

Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy

Metformin is under evaluation as a potential anticancer agent. Expression of total and phospho(Thr172)-adenosine monophosphate-activated kinase-α (AMPKα and pAMPKα(Thr172) respectively), a main metformin target, was examined in radiotherapy treated breast cancers and metformin's ability to modu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yimin, Storr, Sarah J., Johnson, Kerstie, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Morgan, David A.L., Martin, Stewart G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350336/ https://www.ncbi.nlm.nih.gov/pubmed/25427448

Ejemplares similares

IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients
por: Ahmad, Narmeen, et al.
Publicado: (2017)

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
por: Pu, Xuan, et al.
Publicado: (2016)

PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer
por: Alfarsi, Lutfi H., et al.
Publicado: (2020)

Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer
por: Althobiti, Maryam, et al.
Publicado: (2021)

Characterization of the radioresponse of human apical papilla-derived cells
por: Abe, Shigehiro, et al.
Publicado: (2011)

Characterizing the Radioresponse of Pluripotent and Multipotent Human Stem Cells
por: Lan, Mary L., et al.
Publicado: (2012)

Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse
por: Jackson, Isabel L., et al.
Publicado: (2016)

Retrospective assessment of cyclin‐dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer
por: Saidy, Behnaz, et al.
Publicado: (2020)

The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours
por: El Ansari, Rokaya, et al.
Publicado: (2018)

Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes
por: Joseph, Chitra, et al.
Publicado: (2018)

CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer
por: Aiyappa‐Maudsley, Radhika, et al.
Publicado: (2022)

Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments
por: Lee, Ik Jae, et al.
Publicado: (2016)

Corrigendum: Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse
por: Jackson, Isabel L., et al.
Publicado: (2017)

High nuclear MSK1 is associated with longer survival in breast cancer patients
por: Pu, Xuan, et al.
Publicado: (2018)

Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
por: Aleskandarany, Mohammed A, et al.
Publicado: (2012)

Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer
por: Davis, Jillian, et al.
Publicado: (2014)

Identifying key mutations of radioresponsive genes in esophageal squamous cell carcinoma
por: Xu, Xin, et al.
Publicado: (2022)

Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods
por: Lashen, Ayat, et al.
Publicado: (2022)

PP1, PKA and DARPP‐32 in breast cancer: A retrospective assessment of protein and mRNA expression
por: Saidy, Behnaz, et al.
Publicado: (2021)

Integrated Analysis of Key Differentially Expressed Genes Identifies DBN1 as a Predictive Marker of Response to Endocrine Therapy in Luminal Breast Cancer
por: Alfarsi, Lutfi H., et al.
Publicado: (2020)

Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients
por: Martin, Stewart G., et al.
Publicado: (2018)

Exploring Nitric Oxide (NO)-Releasing Celecoxib Derivatives as Modulators of Radioresponse in Pheochromocytoma Cells
por: Brandt, Florian, et al.
Publicado: (2022)

A Radioresponse-Related lncRNA Biomarker Signature for Risk Classification and Prognosis Prediction in Non-Small-Cell Lung Cancer
por: Song, Jiahang, et al.
Publicado: (2021)

The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer
por: Masisi, Brendah K., et al.
Publicado: (2021)

MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours
por: Green, Andrew R, et al.
Publicado: (2016)

Establishment of a 3D Model to Characterize the Radioresponse of Patient-Derived Glioblastoma Cells
por: Strand, Zoe, et al.
Publicado: (2023)

Are triple-negative tumours and basal-like breast cancer synonymous?
por: Rakha, Emad A, et al.
Publicado: (2007)

MYC regulation of glutamine–proline regulatory axis is key in luminal B breast cancer
por: Craze, Madeleine L, et al.
Publicado: (2018)

Assessment of Luminal and Basal Phenotypes in Bladder Cancer
por: Guo, Charles C., et al.
Publicado: (2020)

A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor‐positive disease
por: Storr, Sarah J., et al.
Publicado: (2023)

Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
por: Berge, D L Van den, et al.
Publicado: (2001)

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling
por: Ko, A, et al.
Publicado: (2014)

Identifying Long Non-coding RNA of Prostate Cancer Associated With Radioresponse by Comprehensive Bioinformatics Analysis
por: Xu, Meng, et al.
Publicado: (2020)

Fluctuation in radioresponse of HeLa cells during the cell cycle evaluated based on micronucleus frequency
por: Shimono, Hiroaki, et al.
Publicado: (2020)

Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways
por: Saidy, Behnaz, et al.
Publicado: (2023)

ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
por: Holland, Daniel G, et al.
Publicado: (2011)

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas
por: Kern, Joseph G., et al.
Publicado: (2022)

Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model
por: Borst, Gerben R., et al.
Publicado: (2017)

Inference of tissue relative proportions of the breast epithelial cell types luminal progenitor, basal, and luminal mature
por: Bartlett, Thomas E., et al.
Publicado: (2021)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_26capde9hfvqa0tt5hfmkc5ghb