The p53 transcriptional pathway is preserved in ATM(mutated) and NOTCH1(mutated) chronic lymphocytic leukemias

By using next generation sequencing, we have analyzed 108 B chronic lymphocytic leukemia (B-CLL) patients. Among genes involved in the TP53 pathway, we found frequent mutations in ATM (n=18), TP53 (n=10) and NOTCH1 (n=10) genes, rare mutations of NOTCH2 (n=2) and CDKN1A/p21 (n=1) and no mutations in...

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Detalles Bibliográficos
Autores principales: Athanasakis, Emmanouil, Melloni, Elisabetta, Rigolin, Gian Matteo, Agnoletto, Chiara, Voltan, Rebecca, Vozzi, Diego, Piscianz, Elisa, Segat, Ludovica, Dal Monego, Simeone, Cuneo, Antonio, Secchiero, Paola, Zauli, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350355/
https://www.ncbi.nlm.nih.gov/pubmed/25587027

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