A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy

Mesoderm Inducer in Xenopus Like1 (MIXL1), a paired-type homeobox transcription factor induced by TGF-β family of ligands is required for early embryonic specification of mesoderm and endoderm. Retrovirally transduced Mixl1 is reported to induce acute myelogenous leukemia (AML) with a high penetranc...

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Detalles Bibliográficos
Autores principales: Raymond, Aaron, Liu, Bin, Liang, Hong, Wei, Ciamaio, Guindani, Michele, Lu, Yue, Liang, Shoudan, St. John, Lisa S., Molldrem, Jeff, Nagarajan, Lalitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350356/
https://www.ncbi.nlm.nih.gov/pubmed/25544748

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