Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich’s Ataxia

The genetic defect in Friedreich’s ataxia (FRDA) is the hyperexpansion of a GAA•TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Histone post-translational modifications near the expanded repeats are consistent with heterochromatin formation and...

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Detalles Bibliográficos
Autores principales: Soragni, Elisabetta, Chou, C. James, Rusche, James R., Gottesfeld, Joel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350406/
https://www.ncbi.nlm.nih.gov/pubmed/25798128
http://dx.doi.org/10.3389/fneur.2015.00044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350406/
https://www.ncbi.nlm.nih.gov/pubmed/25798128
http://dx.doi.org/10.3389/fneur.2015.00044

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